全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中武汉市普仁医院肠道微生态诊疗中心为便秘腹泻交替20余年、合并重度抑郁的28岁脑瘫患者实施大小肠序贯肠菌移植，借助肠-脑轴双向调控重建肠道菌群。9月10日患者康复出院，肠道症状与抑郁情绪同步显著改善，显示FMT在肠脑共病中的临床应用潜力。

ENWuhan Puren Hospital's intestinal microecology center treated a 28-year-old patient with two decades of alternating constipation and diarrhea plus severe depression using sequential small- and large-intestine fecal microbiota transplantation, rebuilding gut flora via the gut-brain axis. Discharged on September 10 with both gut and mood symptoms markedly improved, the case highlights FMT's clinical potential in combined gut-brain disorders.

中在第十一届国际功能医学暨长寿科技大会上，锐翌生物秦楠复盘国务院818号令实施四个月的行业变化：FMT获“成熟常规医疗技术”身份，《儿童肠菌移植临床应用管理专家共识（2026）》补齐儿科规范空白，全国超28个省市落地收费编码，西藏率先将FMT纳入医保甲类报销。

ENAt the 11th International Functional Medicine and Longevity Technology Conference, Ruiyi Biotech's Qin Nan reviewed four months of China's State Council Decree 818: FMT is now recognized as a mature routine medical technology, a 2026 pediatric FMT expert consensus has filled a regulatory gap, billing codes are live in over 28 provinces and cities, and Tibet became the first to include FMT in Class-A medical insurance reimbursement.

中北京大学第三医院举办人体微生态精准诊疗与菌剂研发北京市重点实验室启动会，80余位专家与会。会议确立“机制解析—精准诊断—原创制剂—验证转化”研究主线，覆盖精准诊断、菌剂研发、菌群移植与中药调菌等方向，标志着肠道菌群研究正从“发现关联”走向“精准诊疗”。

ENPeking University Third Hospital hosted the launch of a Beijing key laboratory for precision human microecology diagnosis, therapy and microbial agent development, drawing more than 80 experts including academician Chen Wei. The lab sets a research line of mechanism analysis, precision diagnosis, novel microbial agents and translational validation, marking the shift of microbiome research from association findings toward precision diagnosis and intervention.

中美国抗衰老医学科学院（A4M）将于9月24日至27日在纳什维尔举办“Accelerated Microbiome Insights”临床课程，围绕内毒素/LPS与神经炎症、非纤维益生元、肠-甲状腺轴、中年女性脑健康及菌群驱动的心代谢疾病等议题，为功能医学与整合医学从业者提供菌群评估与干预的实操框架。

ENThe American Academy of Anti-Aging Medicine (A4M) will hold its Accelerated Microbiome Insights clinical course in Nashville on September 24-27, covering endotoxin/LPS-driven neuroinflammation, non-fiber prebiotics, the gut-thyroid axis, midlife female brain health and microbiome-driven cardiometabolic disease — equipping functional and integrative medicine clinicians with practical frameworks for microbiome assessment and intervention.

中ScienceDaily 9月18日重点报道：下丘脑Menin蛋白随龄下降可能与驱动全身衰老相关，在小鼠中与炎症、认知衰退、骨量下降和皮肤变薄有关。向20月龄小鼠下丘脑重新导入Menin 30天后，皮肤、骨骼、认知与平衡能力改善并延长寿命；补充D-丝氨酸则可改善认知但不逆转骨骼皮肤变化。

ENScienceDaily highlights research showing that age-related decline of the hypothalamic protein Menin may help drive systemic aging, being linked in mice to inflammation, cognitive decline, bone loss and thinner skin. Re-delivering Menin to the hypothalamus of 20-month-old mice improved skin, bone, cognition and balance within 30 days and extended lifespan, while D-serine supplementation improved cognition without reversing physical aging signs.

中NutraIngredients 行业报道称，微生物组初创企业正把业务重心从消化健康扩展到长寿与健康寿命领域，通过工程菌株、后生元与衰老相关生物标志物把菌群科学转化为抗衰产品管线，菌群干预正在成为长寿经济中的新兴支柱赛道。

ENAn industry report by NutraIngredients notes that microbiome startups are expanding beyond digestive health into longevity and healthspan, converting microbiome science into anti-aging product pipelines through engineered strains, postbiotics and aging-related biomarkers — positioning microbiome intervention as an emerging pillar of the longevity economy.

中NutraIngredients 汇总近期健康寿命与寿命相关补剂科学进展，覆盖细胞健康成分的多成分组合趋势、衰老生物标志物在干预评估中的应用，以及从细胞机制向日常健康寿命产品转化的证据要求，为长寿营养品研发与选品提供循证参考。

ENNutraIngredients rounds up recent healthspan and lifespan supplement science, covering the multi-ingredient stack trend in cellular-health products, the use of aging biomarkers to evaluate interventions, and the evidence standards required to translate cellular mechanisms into everyday healthspan products — a reference point for longevity nutrition R&D and product selection.

中在第七届时光派国际长寿论坛上，时光派联合弗若斯特沙利文发布中英双语《2026全球长寿诊所医学干预分级及落地指南》。其“营养干预”章节指出，长寿营养正从“原料质量”转向“完整产品质量”，完整产品证据成为竞争重点，并以海洋精粹油（SPMs+纯EPA）等循证实践为典型案例。

ENAt the 7th Timeshop International Longevity Forum, Timeshop and Frost & Sullivan released the bilingual 2026 Global Longevity Clinic Medical Intervention Grading and Implementation Guide. Its nutrition intervention chapter highlights a shift from raw-material quality to whole-product quality, with complete product evidence as the new competitive focus, citing evidence-based practices such as marine lipid oils combining SPMs and pure EPA.

中德国康斯坦茨大学团队在EMBO Molecular Medicine发文，首次鉴定肠道细菌（经反刍动物食物链传递）产生的异油酸是核受体LRH-1/NR5A2的配体。小鼠实验显示异油酸可显著降血糖、降血脂并改善脂肪肝，从分子层面揭示完整菌群如何调控全身代谢，为代谢性肝病的菌群靶向干预提供新靶点。

ENResearchers at the University of Konstanz report in EMBO Molecular Medicine the first identification of vaccenic acid — produced by ruminant-derived gut bacteria entering the food chain — as a ligand for the nuclear receptor LRH-1/NR5A2. In mice, vaccenic acid significantly lowered blood glucose and lipids and improved fatty liver, revealing at the molecular level how an intact microbiome regulates whole-body metabolism and opening a new target for microbiome-directed therapy of metabolic liver disease.

中ScienceDaily 报道，日本黑米和绿米品种含有不寻常且可能有益的脂质成分，并且可能比普通白米消化得更慢。这一“有色米”组合被视为功能性食品设计中颇具前景的原料方向，为以谷物为基础的血糖友好型主食开发提供了新思路。

ENScienceDaily reports that black and green Japanese rice varieties contain unusual, potentially beneficial fats and may be digested more slowly than ordinary white rice. This combination positions pigmented rice as a promising ingredient for functional food design, offering new ideas for grain-based, blood-sugar-friendly staple foods.

中新研究显示，膳食蛋白质来源会显著影响血浆晚期糖基化终末产物（AGEs）水平——AGEs与衰老、慢性炎症及代谢疾病密切相关。研究提示，在蛋白质摄入量相同的情况下，选择不同蛋白来源可能带来不同的 AGEs 负荷，为精准营养中的蛋白质来源优化提供了依据。

ENNew research shows that the source of dietary protein significantly affects plasma levels of advanced glycation end products (AGEs), which are closely linked to aging, chronic inflammation and metabolic disease. With protein intake held constant, different protein sources appear to impose different AGE burdens — supporting protein-source optimization as a lever in precision nutrition.

中ScienceDaily 报道，一种源自泡菜的细菌在类肠道环境下能够结合纳米塑料；在小鼠实验中，该益生菌使粪便中检出的纳米塑料量增加一倍以上，提示发酵食品中的微生物或可帮助人体排出纳米塑料，为食品源微塑料暴露的膳食干预提供了全新思路。

ENScienceDaily reports that a kimchi-derived bacterium can bind nanoplastics under gut-like conditions. In mice, the probiotic more than doubled the amount of nanoplastics detected in feces, suggesting that microbes from fermented foods may help the body eliminate nanoplastics — a novel dietary intervention angle against foodborne microplastic exposure.

中澳大利亚药品管理局（TGA）宣布不再允许穿心莲用于新注册的列表药品，这一常见免疫支持类草药成分面临监管收紧。对出口澳洲的补剂品牌而言，含穿心莲配方的新品上市路径受阻，存量产品的标签与合规审查也将趋严。

ENAustralia's Therapeutic Goods Administration (TGA) has announced that Andrographis paniculata will no longer be permitted in newly listed medicines, tightening regulation of a common immune-support botanical. Supplement brands selling into Australia face blocked launch paths for new andrographis formulations and stricter label and compliance reviews for existing products.

中尽管行业已开展15年的反掺假行动，最新数据仍显示植物成分掺假事件呈上升趋势。报道称供应链压力、原料涨价与检测能力不均是主要驱动，凸显第三方身份鉴定、DNA条形码等溯源技术在补剂质量控制中的必要性。

ENDespite 15 years of industry anti-adulteration action, new data shows botanical ingredient adulteration incidents are still rising. Supply chain pressure, raw material price hikes and uneven testing capacity are cited as key drivers, underscoring the need for third-party identity testing and DNA barcoding in supplement quality control.

中新研究为β-羟基-β-甲基丁酸（HMB）在年龄相关肌肉流失（肌少症）管理中的角色提供支持，显示其在维持老年人群肌肉质量与功能方面的潜力，为面向老年营养和健康寿命市场的蛋白辅助成分组合再添证据。

ENNew research supports the role of beta-hydroxy-beta-methylbutyrate (HMB) in managing age-related muscle loss (sarcopenia), showing potential for preserving muscle mass and function in older adults and adding evidence for HMB in protein-companion ingredient stacks targeting the older-nutrition and healthspan market.

中英国食品标准局（FSA）在CBD新食品审批进程中释放“重大里程碑”信号，长期悬而未决的CBD产品合规路径出现松动迹象。行业关注目录确认与产品授权节奏是否加快，但分析提醒企业对最终授权时点与安全数据要求仍应保持谨慎预期。

ENThe UK Food Standards Agency (FSA) has signaled a 'major milestone' in the long-running CBD novel food process, hinting at movement on the stalled compliance pathway for CBD products. Industry is watching whether the public list confirmation and product authorizations will speed up, though analysts caution firms to keep expectations measured on final timing and safety data requirements.

中新华财经观察指出，全球腕戴设备增速放缓，行业竞争已从硬件参数转向医疗级健康监测能力：SKG腕部心电血压记录仪、华为WATCH D2动态血压、OPPO全周期健康管理等头部产品纷纷对标医疗器械标准打磨传感与算法，AI分析将连续体征数据转化为风险预警，推动腕上设备从数据记录者进化为主动健康助手。

ENXinhua Finance Observer notes that as global wrist-worn device growth slows, competition has shifted from hardware specs to medical-grade health monitoring. Leading products such as SKG's wrist ECG-blood-pressure recorder, Huawei WATCH D2 ambulatory blood pressure and OPPO's full-cycle health management are built to medical device standards, with AI converting continuous vitals into risk alerts — turning wearables from data loggers into proactive health assistants.

中新研究综述发现，Ozempic等GLP-1药物虽显著改善血糖、体重与心血管健康，但几乎没有证据表明它们同样改善心理健康、就业、婚姻或整体幸福感。研究提示GLP-1类药物对生活质量的“外溢效应”可能远小于其生理获益，慢病管理仍需配套生活方式与心理支持。

ENNew research finds that while Ozempic and other GLP-1 drugs substantially improve blood sugar, weight and cardiovascular health, there is little evidence they also improve mental health, employment, marriage or overall well-being — suggesting the broader life effects of GLP-1s may be far subtler than their physical benefits, and chronic disease management still requires lifestyle and psychosocial support.

中英国行业专家在讨论中呼吁，食品与营养产业应跨越竞争壁垒联合行动，共同改善国民饮食健康，包括配方改良、负责任营销与公共卫生协作。文章认为，面对肥胖与慢病压力，行业协同将是“食品即健康”议程能否落地的关键。

ENUK industry experts have called on the food and nutrition sector to act collectively across competitive boundaries to improve national dietary health, including reformulation, responsible marketing and public-health collaboration. Facing obesity and chronic disease pressures, they argue, industry coordination will be decisive for whether the 'food as health' agenda delivers.

中9月14日国新办“开局起步‘十五五’”发布会上，国家卫健委主任雷海潮披露：我国居民日均盐摄入约9克、食用油41克，均远超推荐量；三级公立综合医院健康体重管理门诊设置率已超95%；居民健康素养为33.7%，十五五目标力争40%。他强调慢病防控要把健康掌握在自己手里，从以治病为中心转向以健康为中心。

ENAt the State Council's September 14 briefing on the 15th Five-Year Plan, NHC Minister Lei Haichao revealed that Chinese residents consume about 9 g of salt and 41 g of cooking oil daily, far above recommended levels; over 95% of tertiary public hospitals now run weight-management clinics; and national health literacy stands at 33.7% with a target of 40%. He stressed shifting from treatment-centered to health-centered care and empowering individuals in chronic disease prevention.