全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中仁济医院房静远团队在 Cancer Cell 发表多中心 2 期研究：具核梭杆菌阳性的 MSS 转移性结直肠癌，甲硝唑联合替雷利珠单抗与呋喹替尼三联方案抗肿瘤活性可观、毒性可控。甲硝唑在不大范围扰乱菌群的前提下降低该菌丰度，并增强 CD8⁺ T 细胞应答。

ENA multicentre phase 2 trial from Renji Hospital, published in Cancer Cell, combined metronidazole with tislelizumab and fruquintinib in Fusobacterium nucleatum-positive MSS metastatic colorectal cancer, showing meaningful antitumour activity with manageable toxicity. Metronidazole cut F. nucleatum without broad dysbiosis and enhanced CD8+ T-cell responses.

中四川农大团队在 npj Science of Food 以 DSS 小鼠结肠炎与上皮细胞铁死亡模型评估藏茶：减轻体重下降、便血与结肠缩短，抑制 NF-κB、增强 Nrf2 抗氧化，以硫氧还蛋白还原酶（TXNRD）为中介抑制铁死亡，并提升 Akkermansia 丰度、纠正色氨酸与亚油酸代谢紊乱。

ENA Sichuan Agricultural University team tested Tibetan dark tea in DSS mouse colitis and epithelial ferroptosis models. It reduced weight loss, bloody stool and colon shortening, suppressed NF-kB, boosted Nrf2 antioxidant defence and blocked ferroptosis via thioredoxin reductase (TXNRD), while raising Akkermansia and correcting tryptophan and linoleic acid disturbances.

中希伯来大学 Sharabi 团队在 Gut Microbes 报告：色氨酸菌群代谢物吲哚-3-丙酸（IPA）选择性抑制丙酮酸/乳酸与谷氨酰胺驱动的肝糖异生，保留甘油通路。13C 示踪示其降低碳源进入糖异生与 TCA 循环，改变复合体 I 依赖的 NAD⁺/NADH 平衡，改善西方饮食小鼠空腹血糖。

ENHebrew University's Sharabi group reported in Gut Microbes that the tryptophan metabolite indole-3-propionate (IPA) selectively blunts gluconeogenesis from pyruvate/lactate and glutamine while sparing glycerol. 13C tracing showed less carbon entering gluconeogenesis and the TCA cycle, altered complex I-dependent NAD+/NADH balance and suppressed CPS1 urea cycling, improving fasting glucose in Western-diet mice.

中BMT CTN 1801 研究（Nature Medicine）：减低强度预处理者中，移植后菌群「支配事件」第 14 天达峰、约半数样本出现，但组间无差异且与结局无稳定关联。关键差异在次级胆汁酸代谢——具 7α/β-脱羟基能力的梭菌减少与慢性 GVHD 风险升高相关，菌群干预须围绕免疫抑制方案设计。

ENBMT CTN 1801 in Nature Medicine found that after reduced-intensity conditioning, microbiome dominance events peaked at day 14 in about half of samples without differing between arms or tracking outcomes. The key difference was secondary bile acid metabolism: fewer 7-alpha/beta-dehydroxylating Clostridia tracked with higher chronic GVHD risk, so microbiome interventions must fit the immunosuppression regimen.

中北医三院于洋、李蓉团队在 STTT 报告：人参皂苷 Rb1 激活 AMPK、抑制 mTOR 与 NF-κB 炎症信号，降低 40–45 岁女性子宫内膜基质细胞的活性氧、p16/p21 与凋亡。10 月龄小鼠腹腔注射两周后着床点与活产仔数增加，容受性蛋白回升，但仍未回到年轻水平。

ENYu Yang and Li Rong's team at Peking University Third Hospital reported in STTT that ginsenoside Rb1 activates AMPK and suppresses mTOR and NF-kB signalling, lowering ROS, p16/p21 and apoptosis in endometrial stromal cells from women aged 40-45. Two weeks of Rb1 in 10-month-old mice raised implantation sites and live pups, with receptivity proteins recovering but still below young levels.

中ScienceDaily 报道一项小鼠研究：从急性感染中恢复的动物在症状消失后仍出现免疫系统隐性损伤，提示病毒影响可能比临床康复时点更持久，研究者认为疫苗预防或可减轻此类遗留损害。结果来自动物模型，不能直接推及人群，但为感染与免疫衰老的关联提供机制线索。

ENScienceDaily reported a mouse study in which animals recovering from acute infection showed hidden immune damage after symptoms resolved, suggesting viral effects outlast clinical recovery; the researchers note vaccination may reduce such residual damage. The findings are from an animal model and cannot be extrapolated directly to people, but they add a mechanistic clue to infection and immune ageing.

中齐鲁网报道海龟医疗在进博会展示高压氧舱，主打 1.99ATA 接近临床剂量的压力设定与医用级承压设计。企业称其联合中国医科大学及附属第一医院开展的 HBOT 抗衰人体临床研究于 2026 年刊发于《Immunity & Ageing》，并提示单一研究不足为结论，使用须遵专业指导。

ENQilu Net reported a hyperbaric chamber maker showcasing a 1.99 ATA device close to clinical dosing with medical-grade pressure containment. Company disclosures say a human trial of hyperbaric oxygen for ageing with China Medical University and its first hospital appeared in Immunity & Ageing in 2026; the report cautions that one study is not conclusive and use should follow professional guidance.

中中国营养保健食品协会健康老龄化会议上，中国疾控中心刘江美团队介绍健康活力年龄模型：纳入行为膳食、代谢、环境等 24 项可干预危险因素，面向全年龄段成人评估，把复杂风险转译为直观的健康活力年龄，量化生活方式改善的健康寿命收益。同场还讨论口服营养与皮肤健康、AI 筛选抗衰成分。

ENAt the China Nutrition and Health Food Association's healthy ageing conference, Liu Jiangmei's team from the Chinese CDC presented a health vitality age model covering 24 modifiable factors across behaviour, diet, metabolism and environment. It scores adults of all ages and converts complex risk into an intuitive vitality age, quantifying healthy-life gains from lifestyle change. Sessions also covered oral nutrition for skin health and AI ingredient screening.

中瑞金医院与国家内分泌代谢病临床医学研究中心发布七项代谢健康成果：数字化系统整合检验、影像、病史与随访数据，可评估器官年龄及肿瘤、心血管代谢风险；「江南瑞餐」基于江南饮食模式循证研究，联合蚂蚁健康以饮食智能体记录摄入并给出个性化膳食指导，落到一日三餐。

ENRuijin Hospital and the national endocrine and metabolic disease centre released seven advances: a digital system integrating lab, imaging, history and follow-up data to score organ age and tumour and cardiometabolic risk, and the Jiangnan meal plan, built on evidence for the Jiangnan diet and paired with Ant Health's diet agent to log intake and give personalised guidance at everyday meals.

中ScienceDaily 报道一项 2500 余名男性研究：动物蛋白摄入较高、尤其乳制品，与较低睾酮水平相关。研究为观察性设计，只提示关联而非因果，也不代表植物蛋白必然提升睾酮。结果提示讨论男性激素与代谢时，蛋白的「来源结构」应与总量一并考量，仍需干预试验验证。

ENScienceDaily reported a study of over 2,500 men in which higher animal protein intake, especially dairy, was associated with lower testosterone. The design is observational, showing association rather than causation, and does not mean plant protein raises testosterone. Protein source may deserve consideration alongside total intake in male hormonal health, pending intervention trials.

中基于美国全国代表性样本 NHANES（1999–2018）的分析显示，成人每日多摄入 1 盎司当量豆类，心脏代谢疾病患病率低约 19%。作者指出横断面设计无法推断因果、自报膳食或有测量误差，但结果支持把干豆、豌豆、扁豆与鹰嘴豆作为改善心脏代谢健康的膳食策略。

ENAn analysis of the nationally representative NHANES sample (1999-2018) found each additional ounce-equivalent of pulses daily associated with about 19% lower cardiometabolic disease prevalence. The authors note the cross-sectional design cannot establish causation and self-reported diet may carry error, but the results support pulses as a dietary strategy for cardiometabolic health.

中第 23 届中国国际保健博览会 11 月 13–15 日在厦门举行。13 日起密集召开 2026 营养抗衰科技大会、保健食品产业高质量发展大会；14 日营养健康食品大会设益生菌、功能食品、运动营养专场，抗衰科技大会另设生物智造、食药同源、AI 赋能专题，产业供给正向全龄日常健康管理延伸。

ENThe 23rd China International Health Expo ran in Xiamen from 13 to 15 November. From the 13th it hosted the 2026 nutrition and anti-ageing science summit and a health food industry conference; on the 14th the nutrition and health food congress ran probiotics, functional food and sports nutrition tracks, while the summit covered biomanufacturing, medicinal foods and AI.

中镇江市场监管部门公布网络食品虚假宣传第二批典型案例：句容某公司合作账号推广「鱼油凝胶糖果（无糖）」时，把未取得保健食品资质的普通食品列入保健食品榜，暗示改善记忆、调节血脂，并以短视频暗示减肥。认定属引人误解宣传，因初犯、危害轻微且及时改正，不予处罚、以整改替代惩戒。

ENZhenjiang regulators published a second batch of cases against false online food claims. A partner account promoting sugar-free fish-oil gel candy, an ordinary food without health-food registration, ranked it among health foods, implied memory and lipid benefits and hinted at weight loss in videos. Deemed misleading promotion, it drew no penalty as a first, minor and corrected offence.

中伊迪斯科文大学开展随机双盲对照试验，测试抗性淀粉加车前子壳的纤维复方用于坚持低 FODMAP 饮食的肠易激综合征患者：腹痛、腹胀、腹泻或便秘均未加重，肠道菌群组成明显改善，肠道相关焦虑下降。研究者认为车前子延缓抗性淀粉被菌群分解，使其抵达结肠更深处。

ENEdith Cowan University ran a randomised double-blind trial of a resistant starch plus psyllium husk blend in IBS patients on a low-FODMAP diet. Pain, bloating, diarrhoea and constipation did not worsen, microbiota composition improved markedly and gut-related anxiety fell. The team suggests psyllium slows bacterial breakdown of resistant starch so more reaches deeper colon regions.

中2026 特殊食品大会在南宁收官，发布《膳食营养与体重管理专家共识》《(6S)-5-甲基四氢叶酸调研与共识》，以及《中国特殊食品在技术融合创新发展驱动下的产业变革》和 A1/A2 β-酪蛋白检测团体标准。协会与荷兰乳业协会、国际特殊膳食协会签署合作备忘录，同期展出 55 篇学术壁报。

ENThe 2026 Special Food Conference closed in Nanning with an expert consensus on dietary nutrition and weight management and a review and consensus on (6S)-5-methyltetrahydrofolate, plus a report on technology-driven industry change and a group standard for A1/A2 beta-casein testing. The association signed memoranda with Dutch dairy and international special dietary food bodies; 55 posters were shown.

中NutraIngredients Asia 汇总近期亚太新品，达能、澳洲植物基品牌 eimele 与资生堂同台，显示营养品上新正从广谱覆盖转向按人群与场景细分。报道将三者并列比较，反映在货架竞争加剧、消费者要求循证的背景下，品牌更倾向以人群定位、剂型便利与成分配伍建立差异，而非扩充 SKU。

ENNutraIngredients Asia rounded up recent Asia-Pacific launches from Danone, Australian plant-based brand eimele and Shiseido, showing a shift from broad coverage to audience- and occasion-specific positioning. Comparing the three, the report suggests that with crowded shelves and demand for evidence, brands favour clear target groups, convenient formats and considered ingredient combinations over more SKUs.

中中国健康促进基金会在北京举办 2026 年联合国糖尿病日科普活动，主题为「糖尿病：早发现，早行动」，发布健康知识传播激励计划工具包，倡导知晓高危因素、筛查风险、主动健康管理、保持健康体重、综合达标五项行动。与会者指出依从性直接影响结局，创新药进入 2026 版基药目录后加速下沉。

ENThe China Health Promotion Foundation held a Beijing event for UN Diabetes Day 2026 under the theme detect early, act early, releasing a toolkit urging five actions: know risk factors, screen, manage proactively, keep a healthy weight and meet composite targets. Speakers stressed adherence shapes outcomes, and that innovative drugs are reaching communities faster after joining the 2026 essential medicines list.

中北京逐步推广糖尿病全程管理新模式：清华长庚医院与天通苑北社区卫生服务中心联动，构建「专科医师定方案、个案管理师抓统筹、家庭医生管日常」三位一体机制，已规范管理患者 2000 余人。报道引述营养师建议：控糖不必戒主食，粗细搭配、控总量，按蔬菜—蛋白—主食顺序进食，蔬菜占餐盘一半。

ENBeijing is spreading whole-course diabetes management: Tsinghua Changgung Hospital and Tiantongyuan North community health centre built a three-tier model where specialists set plans, case managers coordinate and family doctors handle daily follow-up, with over 2,000 patients managed. A dietitian advises mixing coarse and refined grains, controlling portions and eating vegetables, then protein, then staples, with half the plate vegetables.

中ScienceDaily 报道密苏里大学研究：保持每日作息规律的老年人报告的身体疼痛更少、情绪状态更好。研究把「作息一致性」这一低成本、可自我管理的日常行为与躯体和心理双维度结局联系起来，提示老年健康管理除运动与膳食外，睡眠与活动时间的稳定安排也应纳入常规评估。属观察性证据。

ENScienceDaily reported a University of Missouri study finding older adults with consistent daily schedules reported less pain and better mood. The work links routine consistency, a low-cost self-manageable behaviour, to physical and psychological outcomes, suggesting stable timing of sleep and activity belongs in routine geriatric assessment. The evidence is observational.

中上海奉贤在老年人体检中增加糖化血红蛋白检测，覆盖约 15 万人，筛出 1.6 万例此前未发现的隐匿高血糖。区里构建「筛查—复核—转诊—干预—随访」链条，将糖化血红蛋白≥9% 且无管理记录的 1793 人列为优先复核，由家庭医生联合专科联盟定个体化方案，并对糖尿病前期高危人群做饮食运动干预。

ENFengxian district in Shanghai added HbA1c to elderly checkups, covering about 150,000 residents and finding 16,000 previously undetected hidden hyperglycaemia cases. It built a screen, verify, refer, intervene and follow-up chain, prioritising 1,793 people with HbA1c of 9% or above for review, with family doctors and specialist alliances setting individualised plans and lifestyle intervention for high-risk prediabetes.

中综述指出，小肠靠 2—5 小时快速转运、胆汁冲刷与相对高氧，养出以链球菌、韦荣球菌为主的特有菌群。双酶梭菌上调 DGAT2 促甘油三酯合成；乳酸菌苯乳酸经 PPARγ 减轻高脂与抗生素暴露小鼠增重；代谢物还刺激肠内分泌细胞释放 5-HT 与 GLP-1。作者称无创定位采样仍是活菌药落地的瓶颈。

ENThe review notes that the small intestine's 2–5 hour transit, bile wash and relatively high oxygen shape a distinct community dominated by Streptococcus and Veillonella. Clostridium symbiosum upregulates DGAT2 to drive triglyceride synthesis; Lactobacillus-derived phenyllactic acid acts via PPARγ to limit weight gain in mice on high-fat diets or antibiotics; metabolites also trigger enteroendocrine release of serotonin and GLP-1. Non-invasive site-specific sampling remains the bottleneck for live biotherapeutics.

中瑞金医院团队分析 72 例结直肠癌标本，发现三级淋巴结构富集者的埃希氏—志贺菌属显著增多，细菌正定位在 T、B 细胞包围的结构内。口服福氏志贺菌可在原位与自发肠癌小鼠中诱导该结构、抑制肿瘤，机制为激活 I 型干扰素，驱动树突状细胞分泌 CCL19/CXCL10、滤泡辅助 T 细胞分泌 CXCL13。

ENAnalyzing 72 colorectal cancer specimens, Ruijin Hospital researchers found that tumors rich in tertiary lymphoid structures harbor more Escherichia–Shigella, with bacteria sitting inside T- and B-cell aggregates. Oral Shigella flexneri induced these structures and suppressed tumors in orthotopic and spontaneous mouse models by activating type I interferon, prompting dendritic cells to release CCL19/CXCL10 and follicular helper T cells to release CXCL13; depleting dendritic cells abolished the effect.

中安徽医科大学团队报告，酒精性肝病患者粪便中单形拟杆菌显著减少；给清除菌群的小鼠补充活菌可降低转氨酶、减轻脂肪变与炎症，热灭活菌无效。活菌提升肠与肝内鸟氨酸，后者上调肝脏 Sirt4，恢复线粒体膜电位与嵴结构并平衡 OPA1；药理抑制 Sirt4 后保护作用消失，亚麻籽油可促该菌增殖。

ENAnhui Medical University researchers report that Bacteroides uniformis is depleted in patients with alcohol-related liver disease. Live bacteria, but not heat-killed ones, lowered transaminases and eased steatosis and inflammation in antibiotic-treated mice. Colonization raised intestinal and hepatic ornithine, which upregulated liver Sirt4, restoring mitochondrial membrane potential and cristae and balancing OPA1; pharmacological Sirt4 inhibition abolished protection. Dietary flaxseed oil promoted the strain and improved the phenotype.

中陆军军医大学新桥医院等团队发现，促泌素基因敲除小鼠出现糖尿病并伴焦虑，无菌条件下焦虑消失，粪菌移植可转移。其肠、血、脑丁酸盐降低，前额叶 IDO1、KYNU 上调使喹啉酸蓄积，作为 NMDA 激动剂令锥体神经元过度兴奋。补充丁酸盐或定植产丁酸菌可抑制该通路、缓解焦虑。

ENA team at Xinqiao Hospital found that secretagogin-knockout mice develop diabetes with anxiety-like behavior that vanishes under germ-free conditions and transfers via fecal transplant. Butyrate fell in gut, blood and brain; prefrontal IDO1 and KYNU rose, accumulating quinolinate, which as an NMDA agonist overexcites pyramidal neurons. Butyrate supplementation or colonizing butyrate producers suppressed the pathway and eased anxiety; patients with diabetes and anxiety also had lower plasma butyrate.

中一项发表于《科学》的分析把人类寿命的遗传率从此前估计的 20%—25% 上调到约 55%，意味着基因对寿命的影响长期被低估。研究者认为余下约 45% 由生活方式、医疗可及性、社会经济地位乃至细胞分裂的随机性决定，这为在痴呆与心血管病发生前做遗传分层与早期干预提供了依据，但强调遗传并非宿命。

ENAn analysis in Science raises the heritability of human lifespan from earlier estimates of 20–25% to roughly 55%, suggesting genetics has long been underestimated. The remaining ~45% is attributed to lifestyle, access to care, socioeconomic status and even randomness in cell division. The authors say this supports genetic stratification and earlier intervention before dementia or cardiovascular disease appears, while stressing that genes are not destiny.

中MIT 团队比较 18—39 岁与 60—84 岁受试者夜间约两小时的 fMRI 与脑电：年轻人进入非快速眼动睡眠后慢波增强、脑脊液波随之变大；老年人平均脑脊液波显著更小，且与慢波减弱相关，并非只是睡得少。神经血管耦合与屏气脑血流反应下降可解释部分差异，灰质萎缩越明显者降幅越大。

ENMIT researchers compared adults aged 18–39 and 60–84 during roughly two-hour nighttime fMRI and EEG sessions. In younger adults, non-REM slow waves strengthened and cerebrospinal fluid waves grew; in older adults CSF waves were significantly smaller, tied to weaker slow waves rather than simply less sleep. Reduced neurovascular coupling and blunted breath-hold blood-flow responses explained part of the gap, and greater gray-matter atrophy tracked with larger declines, though some older adults retained youthful flow.

中耶鲁团队汇总 51 项临床研究、110 余项 DNA 甲基化标志（含 16 个表观遗传时钟）发现：二甲双胍、司美格鲁肽与抗 TNF 药物，以及「健康饮食＋运动」能可测量地降低表观遗传年龄；受试的非处方抗衰补剂与部分医疗程序则未见显著效果。作者强调，标志物下降是否等于活得更久、更少得病仍未证实。

ENPooling 51 clinical studies and more than 110 DNA methylation biomarkers including 16 epigenetic clocks, Yale researchers found that metformin, semaglutide and anti-TNF drugs, plus healthy diet combined with exercise, measurably lowered epigenetic age, whereas the over-the-counter anti-aging supplements and some medical procedures studied showed no meaningful effect. The authors stress it remains unproven that lower biomarker age means longer, healthier lives.

中11 月 12 日，2026 上海银发科技产业周「抗衰与长寿」专题会在漕河泾举行。复旦长寿与衰老研究所石雨江提出衰老并非匀速、存在关键拐点，须找到驱动通路才能精准检测干预；华东理工谢静莉的发酵食品益生菌已与闵行区中心医院合作临床；中科院陆炯明提醒饮食限制等干预到老年可能减弱。

ENAt the aging and longevity session of the 2026 Shanghai silver-economy week on Nov 12, Shi Yujiang of Fudan's Institute of Longevity and Aging said aging is not linear but has critical tipping points, and only mapping driver pathways enables precise detection and intervention. Other speakers covered NADH and cellular damage, a fermented-food probiotic now in clinical study with Minhang Central Hospital, and the caveat that dietary restriction may lose benefit in old age.

中中国 6 家三级医院联合开展的随机试验 11 月 12 日发表于《JAMA·肿瘤学》：236 例鼻咽癌同步放化疗患者中，从治疗开始即口服营养补充者疗程结束时体重下降超过 5% 的比例为 65.4%，等摄入连续 3 天低于需求 60% 才启动的常规组为 80.7%，相差 15.3 个百分点。

ENA randomized trial run by six Chinese tertiary hospitals, published Nov 12 in JAMA Oncology, enrolled 236 nasopharyngeal carcinoma patients undergoing concurrent chemoradiation. Those starting oral nutritional supplements at the outset had a 65.4% rate of losing more than 5% of body weight by end of treatment, versus 80.7% in the usual-care arm that waited until intake fell below 60% of needs for three days — a 15.3-point gap. The authors say support should not wait until patients cannot eat.

中耶鲁医学院与责任医师协会在《BMJ 糖尿病研究与治疗》发表 16 周试验：25 名 BMI 31.4 的 2 型糖尿病患者采用不限热量、吃到饱的低脂纯植物饮食。肝内脂肪由 8.8% 降至 5.4%（降 33%），内脏脂肪减 290 立方厘米，HOMA-IR 由 5.0 降至 2.5。样本小、无对照。

ENIn a 16-week trial in BMJ Open Diabetes Research & Care, 25 adults with type 2 diabetes (mean duration 6.6 years, BMI 31.4) ate a low-fat vegan diet to satiety without calorie limits, about 75% of energy from carbohydrate and 10% from fat. Liver fat fell from 8.8% to 5.4% (-33%), visceral fat dropped 290 cm³, body weight fell 6.0 kg and HOMA-IR went from 5.0 to 2.5. The sample was small and uncontrolled.

中《临床营养》发表的随机对照试验纳入 286 例代谢相关脂肪性肝病患者，设三层强度：标准生活方式建议、加个体化营养与每月远程随访、再加认知行为疗法心理支持。18 个月时体重下降 ≥10% 的比例分别为 38.8%、50% 与 71.3%；完整多学科组肝硬度与受控衰减参数持续下降。

ENA randomized trial in Clinical Nutrition assigned 286 MASLD patients to three escalating intensities: standard lifestyle advice alone; plus individualized nutrition and monthly remote follow-up; or plus cognitive-behavioral psychological support. At 18 months, 38.8%, 50% and 71.3% respectively reached at least 10% weight loss. The full multidisciplinary arm also saw sustained falls in liver stiffness and controlled attenuation parameter, with an acute cardiovascular event hazard ratio of 0.36 in higher-risk patients.

中一篇综述梳理营养表观遗传学与女性生殖健康：同一营养暴露会因遗传背景、代谢表型、年龄与激素环境产生不同反应，把人群关联转成临床可用的精准营养仍处早期。作者主张 DNA 甲基化＋转录组＋代谢组的多组学路径，但强调多数标志物在外周血测得，与卵巢、子宫内膜、胎盘的相关性不能假定。

ENA review examines nutritional epigenetics across the female reproductive lifespan, noting that the same dietary exposure produces different responses depending on genetic background, metabolic phenotype, age and hormonal milieu, and that translating population associations into clinical precision nutrition remains early. The authors advocate multi-omics combining DNA methylation, transcriptome and metabolome, but caution that most markers are measured in peripheral blood and cannot be assumed to reflect ovarian, endometrial or placental biology, so routine epigenetic testing is not yet supported.

中11 月 12 日，南宁 2026 特殊食品大会国家食检中心分会上，保健食品追溯码正式启用，这是该品类首次建立全链条统一追溯体系。消费者扫码可查原料来源、注册备案信息、允许声称的保健功能、适宜与不适宜人群、生产批次与经销主体。国家食检中心称，将以此推动婴幼儿配方食品、特医食品的追溯建设。

ENAt the national food inspection center session of the 2026 Special Food Conference in Nanning on Nov 12, China officially activated a traceability code for health foods — the first full-chain unified system for the category. Scanning the code reveals ingredient origin, registration and filing details, permitted health claims, suitable and unsuitable populations, production batch and distributor, with an online feedback channel. The center said the system will accelerate traceability for infant formula and foods for special medical purposes.

中2026 特殊食品大会 11 月 11 日在南宁举行。中国营养保健食品协会会长陈卫提出「五向发力」：向需而研、向新而强、向证而立、向链而聚、向海而兴，强调以循证数据夯实科学根基。张启发主张农医融合推进全谷物行动；谢明勇指出 AI 贯通配方设计与智能制造是精准营养落地路径；会上发布产业变革新书。

ENThe 2026 Special Food Conference opened in Nanning on Nov 11. Association president Chen Wei proposed five directions — research for demand, strength through innovation, standing on evidence, clustering the supply chain and going global — stressing evidence-based science. Zhang Qifa argued for agriculture-medicine integration around whole grains, Xu Tao discussed AI and population cohorts, and Xie Mingyong framed AI-driven formulation and smart manufacturing as the route to precision nutrition. A new industry book was released and MOUs signed with Dutch and international special-dietary associations.

中湖南娄底市市场监管局 11 月 13 日向药店发出提醒函：委托 MCN 机构、主播开展直播带货与短视频科普的，主体责任不得外包，须事前审核脚本话术、留存直播回放与素材台账。保健食品广告需审查备案、不得宣称替代药品或治疗疾病；特医食品不得面向普通人群直播带货。

ENLoudi's market regulator issued a reminder letter to pharmacies on Nov 13: when commissioning MCN agencies or influencers for livestream selling and short-video science communication, primary responsibility cannot be outsourced, and scripts, replays and promotional materials must be pre-reviewed and archived. Health food ads need filing and may not claim to replace drugs or treat disease; foods for special medical purposes may not be livestreamed to general audiences; fake case studies and anxiety marketing are banned.

中《营养学前沿》刊出一项随机双盲安慰剂对照试验：109 名 40—75 岁自报有认知困扰的成年人，每天补充 2 克猴头菇（子实体＋菌丝体）或安慰剂，持续 8 周。结果显示视觉注意力与工作记忆改善优于安慰剂，主观睡眠质量与情绪状态也更好，未报告不良事件。作者提示标准化制剂不等同于日常吃鲜菇。

ENFrontiers in Nutrition published a randomized, double-blind, placebo-controlled trial in which 109 adults aged 40–75 with self-reported cognitive complaints took 2 g of lion's mane (fruiting body plus mycelial biomass) or placebo daily for eight weeks. Visual attention and working memory improved more than placebo, as did subjective sleep quality, morning restorative feel and mood, with no adverse events reported. The authors note standardized extract is not the same as eating fresh mushrooms, and food cannot replace medication.

中江苏自 2024 年起把基层慢病筛防中心建设连续三年纳入省政府民生实事。全省已建成 208 个筛防中心，完成高血压、糖尿病等慢病筛查超 555 万人次、并发症筛查 151.51 万人次，为 51.13 万名患者提供「三高共管」一体化干预。南京栖霞迈皋桥社区门诊量同比增 39%，满意度超 96%。

ENJiangsu has made primary-care chronic disease screening centers a provincial livelihood project for three consecutive years since 2024. It has now built 208 centers, screened more than 5.55 million people for hypertension, diabetes and related conditions plus 1.5151 million for complications, and provided integrated management of the three highs to 511,300 patients. The Maigaoqiao center in Nanjing's Qixia district saw roughly 50,000 visits this year, up 39% year on year, with satisfaction above 96%.

中11 月 13 日晚，广东省卫健委主办的「粤启蓝光，守护糖胖」活动在广州荔湾中心医院启动。今年健康大巴从汕头出发，覆盖 9 市、16 家医院接力、行程超 1500 公里，提供免费血糖、人体成分、肝弹性与眼底早筛，目标覆盖 30 万群众。专家强调体重每减 1 公斤，糖尿病风险明显下降。

ENOn the evening of Nov 13, Guangdong's health commission launched its diabetes and obesity campaign in Guangzhou ahead of the 20th UN Diabetes Day. This year's mobile clinic bus started in Shantou and covered nine cities with 16 hospitals over more than 1,500 km, offering free glucose, body composition, liver stiffness, retinal and cognitive screening to a target of 300,000 residents. Chen Hong of the provincial diabetes center proposed knowing one's weight standard, weight change and management method, noting risk falls clearly with each kilogram lost.

中11 月 14 日，石家庄市卫健委举办「家庭医生签约服务—我们这一年」活动。全市组建 4331 支「四位一体」家医团队，并在楼宇公示团队信息。现场启动主动健康试点：即日起至明年 1 月 20 日，在 4 家社区卫生服务中心用声纹技术为 65 岁以上老人做认知障碍快筛，2027 年扩至 20 家。

ENOn Nov 14 Shijiazhuang's health commission held a review event for family doctor contracting. The city has divided service grids and formed 4,331 four-in-one family doctor teams, fixed the second Saturday of each month as a community visiting day and posted team details in residential buildings. An active-health pilot also launched: from now to Jan 20 next year, four community health centers will use voiceprint technology to screen and intervene for cognitive impairment in residents over 65, expanding to 20 centers in 2027.

中11 月 13 日国家卫健委发布会聚焦立冬健康与健康素养：我国居民健康素养 2025 年为 33.69%，距 2030 年 40% 目标仍有差距。专家提醒「0 蔗糖」只针对蔗糖、「零添加」不等于低糖低盐；新标签标准强制标示饱和脂肪与糖，2027 年 3 月 16 日起禁用「零添加」等用语。

ENA Nov 13 National Health Commission briefing focused on winter health and health literacy, which reached 33.69% in 2025, still short of the 40% target for 2030. Experts warned that zero sucrose covers only sucrose, no additives does not mean low sugar or salt, and non-fried does not mean low fat; the new labeling standard mandates saturated fat and sugar declarations and bans no-additive claims from March 16, 2027. COPD and diabetes day themes stress early diagnosis and early action.

中郭旭生团队在《Aging Cell》发表研究：自然衰老小鼠的糖耐量受损存在性别差异，老年雄鼠循环瓜氨酸显著下降。灌服植物乳植杆菌 AS21 可调节肠黏膜菌群、增强瓜氨酸合成，促进肠内分泌细胞分泌 GLP-1，改善雄鼠糖耐量，而对糖耐量本就良好的雌鼠影响有限。

ENGuo Xusheng's team reported in Aging Cell that glucose intolerance in naturally aged mice is sex-biased, with aged males showing lower circulating citrulline. Lactiplantibacillus plantarum AS21 reshaped gut mucosal microbiota, strengthened citrulline synthesis and GLP-1 release from enteroendocrine cells, improving glucose tolerance in males while barely affecting females.

中麻省理工团队基于 FS² 严格喂养试验发现，受控热量限制使体重下降约 12%，菌群发生可重复重构：Akk 菌与 Alistipes finegoldii 上升、青春双歧杆菌下降。随后 20 周三组不同碳水脂肪比饮食并未显著区分菌群。Shuttleworthia 丰度变化与减重后能量消耗能否维持相关。

ENUsing the tightly controlled FS² feeding trial, MIT researchers found that a roughly 12% weight loss produced reproducible microbiota shifts, with Akkermansia muciniphila and Alistipes finegoldii rising while Bifidobacterium adolescentis fell. Twenty weeks of diets at 20%, 40% or 60% carbohydrate failed to separate microbiota profiles; Shuttleworthia abundance tracked whether energy expenditure was preserved.

中巢式病例对照研究比较 69 例随访期内确诊克罗恩病者与 69 名匹配健康对照：临床前组粪便神经氨酸酶活性显著更高，每升高一个标准差，未来发病风险增加 54%（OR 1.54）。该活性与粪便钙卫蛋白、活泼瘤胃球菌丰度正相关，提示它更像临床前炎症的一环而非独立预测因子。

ENIn a nested case-control study of 69 people later diagnosed with Crohn's disease and 69 matched controls, preclinical cases had significantly higher faecal neuraminidase activity; each standard deviation raised future risk by 54% (OR 1.54). The activity correlated with faecal calprotectin and Ruminococcus gnavus abundance, suggesting it reflects ongoing preclinical inflammation rather than acting alone.

中健康成人吞服可采集数据的电子胶囊，连续 8 天记录转运时间、温度、pH 与肠道收缩。高频饮用组（8 天中至少 3 天、每天 1—5 杯）菌群多样性更高，小肠 pH 显著更低，结肠收缩更频繁。作者强调这是观察性研究，尚不能确认因果，下一步将做控量干预试验。

ENHealthy adults swallowed data-logging capsules that tracked transit time, temperature, pH and contractions for eight days. High-frequency drinkers — coffee on at least three of eight days, one to five cups daily — had greater microbial diversity, notably lower small-intestinal pH and more frequent colonic contractions. The authors stress the observational design cannot establish causation and plan a controlled intervention.

中这篇观点文章指出，现有脑衰老证据过度集中于高收入国家、且常用教育或收入等单一指标。作者主张用多社会风险评分、社会脆弱性指数等复合工具，经本地验证后刻画暴露组，并梳理应激、炎症、代谢、血管与表观遗传五条「生物学嵌入」通路，呼吁情境敏感的多层次全生命周期研究。

ENThis Perspective argues that brain-aging evidence is skewed toward high-income countries and often relies on single proxies such as education or income. The authors call for composite tools — polysocial risk scores, social vulnerability indices — harmonised, locally validated and combined with the exposome, and map five biological-embedding pathways: stress, inflammation, metabolic, vascular and epigenetic.

中在上海银发科技产业周大健康专场上，华东医院院长保志军指出我国预期寿命已达 79.25 岁，但与健康寿命仍有 8—10 年差距，衰弱带来的全身性问题常被忽略。该院牵头制定上海市地方标准《老年衰弱筛查规范》，用 10 道题的量表做早期识别，再配合营养、运动、用药优化与认知干预。

ENAt the Shanghai Silver Tech Industry Week, Huadong Hospital president Bao Zhijun noted that life expectancy in China has reached 79.25 years yet trails healthy life expectancy by eight to ten years, with frailty often overlooked. The hospital led a Shanghai local standard for frailty screening built on a ten-question scale, paired with nutrition, exercise, medication review and cognitive support.

中四川大学吴尧团队把 MXene@BaTiO₃ 压电异质结锚定于 PEEK 表面，超声下输出 1.2 微安脉冲电流，经 PI3K/Akt/MDM2 促 p53 降解，恢复 TRAP1–CypD 对线粒体通透孔的调控，使衰老骨髓间充质干细胞转向氧化磷酸化供能；大鼠股骨缺损模型中新骨与骨小梁明显增加。

ENWu Yao and Luo Bin at Sichuan University anchored a MXene@BaTiO₃ piezoelectric heterojunction onto PEEK, generating roughly 1.2 microamps of pulsed current under ultrasound. The signal drove PI3K/Akt/MDM2-mediated p53 degradation, restored TRAP1–CypD control of the mitochondrial permeability pore and shifted senescent mesenchymal stem cells toward oxidative phosphorylation, improving bone healing in rat femoral defects.

中《美国新闻与世界报道》邀请 63 位衰老与长寿领域专家、临床医生、研究者与营养师评估健康衰老的关键因素，得票前三依次是持续规律运动、营养均衡饮食与高质量睡眠，昂贵补充剂与新型疗法均未进入前列。报道同时引用全球共识，建议老年人每周 2—3 次抗阻训练并搭配有氧、平衡与柔韧练习。

ENUS News & World Report asked 63 aging and longevity specialists, clinicians, researchers and dietitians what matters most for healthy aging. Regular exercise, a balanced diet and restorative sleep took the top three spots, with no costly supplement or novel therapy close behind. The report also cites a global consensus advising two to three resistance sessions weekly plus aerobic, balance and flexibility work.

中上海六院营养科主任葛声分享：一位 75 岁女性长期服用多种抗衰补剂，蛋白质摄入却不足每公斤体重 0.6 克，一年无主动减重却掉了 4 公斤，握力仅 19 公斤。她强调精准营养应基于膳食调查、体重与握力等评估，先判断该不该补，再谈补什么，并排查补剂与现有用药的相互作用。

ENGe Sheng, nutrition director at Shanghai Sixth Hospital, described a 75-year-old woman taking multiple anti-aging supplements whose protein intake was under 0.6 g per kilogram; she lost 4 kg in a year without dieting and had a grip strength of only 19 kg. Ge argues precision nutrition starts with dietary assessment, weight and grip strength — deciding whether to supplement before what to supplement.

中意大利国家胃肠病研究所将 66 名 30—65 岁 MASLD 患者随机分组，干预组每日吃 400 克整颗 Navelina 橙子共 4 周。果糖胺呈下降趋势但未达显著，维 A、维 C 与膳食糖摄入升高，空腹血糖、胰岛素与 HOMA-IR 无显著变化。作者提示果糖胺受白蛋白影响且未检测，结论需谨慎。

ENItaly's national gastroenterology institute randomised 66 adults aged 30 to 65 with MASLD to 400 g of whole Navelina oranges daily for four weeks or no oranges. Fructosamine trended lower without reaching significance, vitamin A and C intake rose, and fasting glucose, insulin and HOMA-IR were unchanged. The authors caution that albumin, which affects fructosamine, was not measured.

中瑞典运动营养公司 Maurten 收购加州 Calorify，把双标水（DLW）检测纳入自身体系，创始人 Hari Mix 将领导新设研究部门 M. Labs。DLW 通过氘与氧-18 的消除速率推算二氧化碳生成与总能量消耗，全球累计仅约 3—4 万次检测；双方希望把补碳与补能方案从估算变成实测。

ENSwedish sports nutrition firm Maurten acquired California-based Calorify, bringing doubly labelled water testing in-house; founder Hari Mix will lead a new research unit, M. Labs. DLW infers carbon dioxide production and total energy expenditure from how deuterium and oxygen-18 wash out of the body, a method used in only 30,000 to 40,000 tests worldwide, mostly in academia.

中上海交大与新加坡国大团队整合数十项研究提出长寿食物金字塔：碳水供能比维持在 50% 左右死亡风险最低；膳食纤维充足者全因死亡风险降 10%—23%，重度摄入超加工食品者高 15%—30%。蛋白质方面，青年期 15%—20%，中年宜降动物蛋白、增植物蛋白，65 岁后回调至 15%—20%、优先鱼类。

ENA review from Shanghai Jiao Tong University and the National University of Singapore proposes a longevity food pyramid: carbohydrate at about 50% of energy carries the lowest mortality, adequate fibre lowers all-cause death by 10% to 23%, and heavy ultra-processed food intake raises it by 15% to 30%. Protein should sit at 15% to 20% in youth, shift toward plants in midlife and return to 15% to 20% after 65.

中首尔光州药局推出「AI 营养补充剂咨询」：用户输入睡眠、饮食、运动等信息后，系统从 8 个品牌 265 款产品中推荐 1—3 款并说明理由，功能声称按韩国食品医药品安全处获批原文展示；孕妇、哺乳期或正在服药者直接转接药师。开发方称成本较外包降低约九成，已在首尔三家药房落地。

ENGwangju Pharmacy in Seoul launched an AI supplement consultation service that takes sleep, diet and exercise inputs, then picks one to three products from 265 items across eight brands with stated reasons, displaying only MFDS-approved claims. Pregnant, breastfeeding or medicated users are routed to a pharmacist. The developer says costs fell about 90% versus outsourcing and three Seoul pharmacies have adopted it.

中针对健全适老食品供给体系的建议，市场监管总局答复称将配合制定适老食品安全基础标准，在保健食品注册端严格安全性、保健功能与质量可控性审查，在备案端持续扩大原料目录与备案产品范围，推进注册备案双轨制，并鼓励研发适合老年人咀嚼吞咽和营养需求的产品。

ENResponding to a legislative proposal on food for older adults, the State Administration for Market Regulation said it will help set baseline standards, tighten safety, function and quality reviews in health food registration, keep widening the ingredient catalogue and filing scope, and encourage products suited to older consumers' chewing, swallowing and nutritional needs.

中新京报调查发现多款固体饮料以「全营养配方」「透析专用」等擦边特医食品的术语面向肾透析人群销售，其中一款具备保健食品资质的产品在不同店铺分别宣称「透析专用」与「试管备孕」。报道后 6 款产品原链接全部下架，部分重新上架时删去暗示性表述。2021 年总局公告已明确固体饮料不得暗示适用特定人群。

ENA Beijing News investigation found powdered drinks marketed to dialysis patients with terms borrowed from medical foods, such as complete nutrition formula or dialysis-specific; one product with health food status was pitched as dialysis-only in one store and fertility-support in another. Six listings were removed and some returned without the claims, which a 2021 regulator notice already prohibits.

中北京互联网法院审结一起直播带货纠纷：主播李某在直播间宣称茶叶可护眼、改善耳鸣，益生菌能治疗自闭症等疾病，平台多次警告后永久关闭其商品分享功能。法院认定茶叶与益生菌属普通商品，虚构医疗功效构成虚假宣传，平台处罚合理，驳回其恢复权限的诉讼请求。

ENBeijing Internet Court ruled against a livestreamer, surnamed Li, who told viewers that tea improves eyesight and tinnitus and that probiotics treat autism. After repeated warnings the platform permanently disabled his product-sharing function; the court held that tea and probiotics are ordinary goods and inventing medical effects constitutes false advertising, so the penalty stands.

中江苏高邮 60 岁以上人口占比达 34%，以县域医共体为龙头建成 2 家县级慢病管理中心，上线慢病全程健康管理系统，实现筛查到考核的全流程闭环，并建成 8 家健康管理型医院、5 家基层慢病筛防中心，常态化管理高血压、糖尿病、慢阻肺患者 9.88 万例；2025 年重大慢病过早死亡率降至 7.89%。

ENWith 34% of residents over 60, Gaoyou in Jiangsu built two county-level chronic disease centres on its medical consortium, launched a full-path management system covering screening through audit, and added eight health-management hospitals plus five primary-care screening centres. It now routinely manages 98,800 patients with hypertension, diabetes or COPD, and premature mortality from major chronic diseases fell to 7.89% in 2025.

中云南省政府办公厅印发《中医药振兴发展「十五五」规划》，要求二级及以上公立中医医院普遍设置老年病科与急诊科，持续推进老年中医药健康中心建设，鼓励有条件的医院开设体重管理门诊及心理、睡眠门诊，并推动 80% 的社区卫生服务中心、乡镇卫生院规范开展 6 类 15 项以上中医适宜技术。

ENYunnan's provincial government issued a five-year plan for traditional Chinese medicine that requires geriatric and emergency departments in all secondary and higher public TCM hospitals, backs geriatric TCM health centres, encourages weight-management, psychological and sleep clinics, and targets 80% of community health centres and township hospitals delivering at least 15 approved TCM techniques across six categories.

中南京雨花台区在西善桥社区卫生服务中心设运动促进健康站，与健康体重管理门诊同处基层慢病筛防中心，居民可一站式完成就诊、并发症筛查、体质测评与运动评估。团队按「1+3+N」配置，实行五色分层管理与健康积分。建站至今服务 5434 人次、开具运动处方 1305 份、跟踪干预 217 人。

ENYuhuatai district in Nanjing placed an exercise-for-health station inside Xishanqiao community health centre, alongside a weight-management clinic in the primary chronic disease screening hub, so residents can complete visits, complication screening, fitness testing and exercise assessment in one stop. A 1+3+N team uses five-colour risk tiers and health points; the site has logged 5,434 visits and 1,305 exercise prescriptions.

中11 月 11—12 日，2026 上海银发科技产业周在徐汇漕河泾举行，以「智赋银龄·场景共创」为主题，为上海首个银发科技场景样本街镇（试点）授牌，成立 AI 银发向善共同体与银发数据、数字创意创新联合体，并围绕老年人主动健康、合理用药发布多份倡议；华东理工大学牵头的数据实验室落地徐汇。

ENThe 2026 Shanghai Silver Tech Industry Week ran on 11-12 November in Xuhui under the theme of technology for ageing, awarding the city's first model town pilot for elder-tech scenarios. It launched an AI-for-good in ageing consortium and a silver data and creative innovation alliance, issued pledges on active ageing and appropriate medication, and landed a data lab led by East China University of Science and Technology.

中香港浸会大学王凯亮团队联合复旦肿瘤医院，11 月 10 日在《自然-代谢》报告：结直肠癌患者肿瘤与粪便中胆固醇代谢物 4-C-3 偏低。肠菌把胆固醇变成 4-C-3，后者既阻断 EGFR，又把突变型 KRAS 锁在非活性态；口服 4-C-3 或用产该分子的菌，均在临床前模型缩小肿瘤。

ENA team led by Wang Kailiang of Hong Kong Baptist University, with Fudan University Shanghai Cancer Center, reported in Nature Metabolism on Nov 10 that colorectal cancer patients have markedly lower levels of the cholesterol metabolite 4-C-3 in tumours and stool. Gut bacteria convert cholesterol into 4-C-3, which blocks the EGFR extracellular domain and holds mutant KRAS in an inactive state; oral 4-C-3, or the native producer Oscillibacter ruminantium and an engineered E. coli, shrank tumours in preclinical models with no obvious toxicity.

中广医肿瘤医院郭松鹤、中山大学张革与张晓实团队 11 月 9 日在《细胞报告医学》报告，齿双歧杆菌在口腔与肠道多为共生菌，进入肿瘤后经 Akt/ERK 促增殖、诱导 MMP3 增强转移；其 GABA 经 FOXA2 上调 P-糖蛋白，削弱 5-FU 与奥沙利铂疗效。79 例结直肠癌中菌量高者生存更差。

ENGuo Songhe of the Affiliated Cancer Hospital of Guangzhou Medical University, with Zhang Ge and Zhang Xiaoshi of Sun Yat-sen University, reported in Cell Reports Medicine on Nov 9 that Bifidobacterium dentium is largely commensal in the mouth and gut but, once inside tumours, drives proliferation via Akt/ERK and metastasis via MMP3; its metabolite GABA raises P-glycoprotein through FOXA2 and blunts 5-fluorouracil and oxaliplatin. Among 79 colorectal cancers, higher intratumoural loads predicted worse overall and disease-free survival.

中中国农业大学团队在《民族药理学杂志》以小鼠模型报告，麋鹿茸粉可减轻肾脏损伤与衰老表型、改善肾功能，同时提高 Akkermansia 与 Lachnospiraceae 丰度、降低 Desulfobacterota 并促进乙酸钠生成；粪菌移植与 HK-2 细胞实验证实菌群及代谢物参与其中。

ENA China Agricultural University team reported in the Journal of Ethnopharmacology that, in mice, milu antler powder reduced kidney tissue damage and senescence markers and improved renal function, while raising Akkermansia and Lachnospiraceae_NK4A136_group, lowering Desulfobacterota and boosting sodium acetate. Faecal microbiota transplantation and HK-2 cell experiments confirmed that the microbiome and its metabolites mediate the protection.

中瑞典卡罗林斯卡学院团队 11 月 9 日在《自然-通讯》报告，在患者脑组织、小鼠模型与培养神经元中识别出两种均能损伤神经细胞的 β 淀粉样小聚集体，其中只有一种会继续长成斑块。团队此前发现的 BRICHOS 蛋白可抑制有害亚型生成；小鼠中干预后斑块与炎症减少，认知测试表现改善。

ENKarolinska Institutet researchers reported in Nature Communications on Nov 9 that they identified two small amyloid-beta aggregates that both damage neurons in patient brain tissue, mouse models and cultured neurons, yet only one goes on to seed plaques. The BRICHOS protein the team had previously found suppresses formation of the harmful subtype; in mice it lowered plaque burden and inflammation and improved cognitive test performance.

中11 月 11 日《自然-衰老》报告，衰老使人类自然杀伤细胞出现脂质堆积、膜流动性升高与皮层硬度下降，上游是视黄醇—SREBP1—ELOVL6 脂肪生成轴。该轴重塑 NK 细胞生物力学并限制免疫监视，提示干预脂质代谢或可恢复老年免疫细胞的机械适应与杀伤能力。

ENNature Aging reported on Nov 11 that ageing drives human natural killer cells into a lipid-laden, more fluid and less stiff state, upstream of which sits a retinol–SREBP1–ELOVL6 lipogenic axis. The axis remodels NK cell biomechanics and constrains immune surveillance, suggesting that targeting lipid metabolism might restore mechanical fitness and killing capacity in aged immune cells.

中11 月 10 日《自然-衰老》报告，阿尔茨海默病患者脑组织与 5×FAD 小鼠中，线粒体来源囊泡（mtV）释放明显增多；把模型鼠脑来源的 mtV 给予受试动物后，可经传递小胶质细胞 Ggt1 推动病理进展。研究为「线粒体—囊泡—神经炎症」这条通路补上了可干预的节点。

ENNature Aging reported on Nov 10 that release of mitochondria-derived vesicles (mtVs) is enriched in brain tissue from Alzheimer's patients and 5×FAD mice; administering brain-derived mtVs propagated pathology through microglial Ggt1. The work adds a targetable node to the mitochondria–vesicle–neuroinflammation axis behind cognitive decline.

中一项果蝇研究显示，在磁屏蔽环境中，携带 Pink1 缺陷（模拟帕金森病线粒体障碍）的果蝇寿命延长约 20%，但攀爬能力进一步下降；健康果蝇部分年龄段的运动表现改善却未见延寿。研究者测到复合体Ⅱ参与能量代谢的能力增强、自由基信号改变，但细胞如何感知磁场仍未厘清。

ENIn fruit flies kept in a magnetically shielded environment, those carrying a Pink1 defect that mimics Parkinsonian mitochondrial dysfunction lived about 20% longer, though their climbing ability fell further; healthy flies moved better at some ages but did not gain lifespan. Complex II engagement in energy metabolism rose and radical signals shifted, yet how cells sense the magnetic field remains unclear.

中圣路易斯华盛顿大学彭广勇团队 11 月 6 日在《细胞报告医学》报告，乳腺癌、结直肠癌与肺癌中积聚的衰老 T 细胞，通过富含脂质的衰老相关分泌表型重编程肿瘤代谢并激活 STAT1/STAT3，推动肿瘤生长、转移、干性与化疗耐药；清除衰老 T 细胞或打断脂质串扰，可在体内抑制进展。

ENA team led by Peng Guangyong at Washington University in St. Louis reported in Cell Reports Medicine on Nov 6 that senescent T cells accumulating in breast, colorectal and lung tumours reprogram tumour metabolism and activate STAT1/STAT3 through a lipid-rich senescence-associated secretory phenotype, driving growth, metastasis, stemness and chemoresistance; clearing these cells or blocking the lipid crosstalk suppressed progression in vivo.

中进博会期间，仙乐健康展示 JsRight 精准营养平台，用算法把年龄、生活方式与健康目标映射到具体配方，观众可在互动屏体验「AI 营养师」识别需求。研究院与德国莱布尼茨衰老研究所启动联合创新基金支持衰老干预早期研究，并与拜耳共建联合实验室、携手美健乐发布口服营养品循证体系。

ENAt the China International Import Expo, Sirio Health showcased its JsRight precision nutrition platform, which maps age, lifestyle and health goals onto formulas, letting visitors try an AI nutritionist on interactive screens. Its research institute launched a joint innovation fund with the German Leibniz Institute on Aging for early-stage ageing research, opened a joint lab with Bayer and released an evidence framework for oral nutrition products with Meijianle.

中大豆苷元经肠菌代谢生成的 S-雌马酚，对 ERβ 的选择性约为 ERα 的 9—13 倍，可绕开「是否为雌马酚产生者」的个体差异。综述引用的 160 例绝经后非产生者试验中，每日 10 毫克、持续 12 周后潮热频率较基线下降 58.7%，安慰剂组为 34.5%，未见子宫内膜增厚等严重不良事件。

ENS-equol, produced when gut bacteria metabolise daidzein, binds ERβ with roughly 9–13 times the selectivity of ERα and sidesteps whether a woman is an equol producer. In a 160-woman trial of postmenopausal non-producers cited in the review, 10 mg daily for 12 weeks cut hot flush frequency by 58.7% from baseline versus 34.5% on placebo, with no endometrial thickening or serious adverse events.

中一项为期六个月的干预让受试者每日摄入 25 克带皮烤花生、32 克花生酱，或宏量营养素相当的对照黄油；花生组血浆极长链饱和脂肪酸上升。在 EPIC-Potsdam 的 774 例 2 型糖尿病病例队列中，这类与花生相关的血脂变化对应发病风险降低 11%，BMI 可解释其中大部分关联。

ENIn a six-month trial, participants ate 25 g of skin-on roasted peanuts, 32 g of peanut butter or a macro-matched control butter daily; the peanut arms showed higher circulating very-long-chain saturated fatty acids. In the EPIC-Potsdam case-cohort of 774 type 2 diabetes cases, these peanut-related lipid shifts corresponded to an 11% lower risk, with BMI explaining most of the association.

中拉夫堡大学随机交叉试验纳入 24 名健康成人，比较四种补剂条件：急性摄入咖啡因会升高动脉僵硬度，而同服 400 毫克甜菜根来源膳食硝酸盐后，僵硬度指标与安慰剂条件相当。作者提醒结论不适用于长期咖啡因使用者或心血管病患者，该研究由原料商 Bio-Gen Extracts 资助。

ENA randomised crossover trial at Loughborough University tested four supplement conditions in 24 healthy adults: acute caffeine raised arterial stiffness, but co-ingesting 400 mg of beetroot-derived dietary nitrate brought stiffness measures back in line with placebo. The authors caution the findings may not extend to chronic caffeine users or people with cardiovascular disease, and the study was funded by ingredient supplier Bio-Gen Extracts.

中在美国心脏协会 2026 科学年会上发布的初步研究，梳理 FDA 安全报告中含咖啡因与兴奋剂产品相关的心血管急症记录，发现心脏骤停、心梗等报告频率显著高于不含此类成分的产品，18—34 岁人群占比突出。研究属相关性观察，不能证明因果；该品类销售额 2024 年已超 200 亿美元。

ENPreliminary research presented at the American Heart Association's 2026 Scientific Sessions reviewed FDA safety reports of cardiovascular emergencies and found that products containing caffeine and other stimulants appeared far more often in reports of cardiac arrest and heart attack than products without them, with adults aged 18–34 accounting for a substantial share. The findings are correlational, not causal; the category topped $20 billion in US sales in 2024.

中Vireo Systems 宣布扩建内布拉斯加 Plattsmouth 工厂，新增约 7 万平方英尺用于 CreaBoost 的生产、仓储与配送，设计年产能 500 万公斤，计划 2027 年 3 月试产、二季度满产。该规格此前由单一海外伙伴生产后进口美国，本土化后将先满足本土需求，再供应全球市场。

ENVireo Systems is expanding its Plattsmouth, Nebraska plant by roughly 70,000 square feet to make, store and distribute CreaBoost, with a designed annual capacity of 5 million kg, pilot production in March 2027 and full output targeted for the second quarter. The premium specification had been made by a single overseas partner and imported; domestic output will serve US demand first, then global markets.

中四川省市场监管局发布《四川省保健食品会议营销合规指引》，要求会前报备主体资质、场地、推介产品与参与人员，活动中对样品展示区、讲解区、公示区与消费者活动区实行全覆盖同步录音录像，留存不少于两个月，并明确投诉处理、先行赔付与预收款兑付要求，把监管关口前移。

ENSichuan's market regulator issued compliance guidance for health-food sales seminars, requiring organisers to file entity qualifications, venue, products and staff before the event and to make synchronised audio-video recordings covering the display, presentation, disclosure and consumer areas, kept for at least two months. It also sets rules on complaint handling, advance compensation and prepayment refunds, moving supervision upstream.

中新品观察显示，运动营养正从训练场景走向日常：GLP-1 用户带动「维持肌肉＋轻负担蛋白」需求，复合补水与蛋白的剂型取代厚重奶昔；乳清蛋白因需求与社交平台「proteinmaxxing」热潮涨价，促使品牌考虑替代蛋白来源。日本福光屋 10 月推出米发酵能量饮升级版 VATEN F，主打纤维与饱腹。

ENNew launches show sports nutrition moving from training days to everyday use: GLP-1 users are driving demand for muscle-maintaining, lighter protein formats, and combined hydration-plus-protein products are displacing heavy shakes. Rising whey prices, fuelled by demand and the social-media 'proteinmaxxing' trend, are pushing brands toward alternative protein sources; Japan's Fukumitsuya launched rice-fermented energy drink VATEN F in October, pitched on fibre and fullness.

中浙大二院泛血管与代谢中心把风险评估、体重管理、用药指导与随访串成一条链：体重管理中心做多学科减重，健康管理中心以「家庭医生＋多学科专家团队」长期跟踪，大数据平台整合血糖、血压、血脂做风险分层并向医生推送干预提示。评价指标也从就诊感受延伸到危险因素控制与随访连续性。

ENThe pan-vascular and metabolic centre at the Second Affiliated Hospital of Zhejiang University links risk assessment, weight management, medication guidance and follow-up: a weight centre handles multidisciplinary slimming, a health management centre tracks patients long term with family doctors plus specialists, and a data platform integrates glucose, blood pressure and lipids for risk stratification and clinician prompts. Evaluation now extends from patient experience to risk-factor control and follow-up continuity.

中奉贤区卫健委以 14 条举措推进健康服务便利化：25 家医疗机构设立健康管理（人才健康服务）中心，与 29 家商会一对一结对，提供中医体质辨识、体脂检测并动态更新电子健康档案；家庭医生可开延伸处方与长处方，居民还能经社区预约二三级医院专家，社卫与产业园区一对一结对弹性排班。

ENFengxian's health commission is rolling out 14 measures to make care more accessible: 25 medical institutions have set up health management centres for talent, paired one-to-one with 29 business chambers to offer TCM constitution assessment, body-fat testing and continuously updated electronic records. Family doctors can issue extended and long prescriptions, residents can book specialist appointments through community centres, and each community clinic is paired with an industrial park on flexible schedules.

中呼图壁县投入 288.78 万元，在县总医院妇幼保健院分院及 5 个乡镇建成 6 个慢病医防融合门诊：配备一体化设备，规范高血压、高血糖、高血脂、高尿酸「四高」筛查，整合用药指导、健康宣教与心理干预，按诊前、诊中、诊后管理；依托家庭医生团队入户随访、送药上门。

ENHutubi county invested 2.89 million yuan to build six integrated chronic disease clinics at the county hospital's maternal and child branch and five township hospitals. Each is equipped for one-stop testing and standardises screening for high blood pressure, glucose, lipids and uric acid, combining medication guidance, health education and psychological support across pre-visit, in-visit and post-visit stages, with family doctor teams doing home follow-up and drug delivery.

中青岛把紧密型医联体与 HCH 连续营养健康服务模式结合，形成「营养服务在社区、干预在医院、指导在家庭」的链条：牵头医院在基层设联合营养门诊，为「三高一慢」开营养处方；已培训基层医务人员 141 人次、配备营养指导员 3220 名，西海岸新区把 8.92 万人纳入营养干预与健康体重管理网络。

ENQingdao is combining tightly knit medical alliances with the hospital-community-home (HCH) continuous nutrition model, so that nutrition services sit in the community, intervention in hospitals and guidance at home. Lead hospitals run joint nutrition clinics in primary care and issue nutrition prescriptions for hypertension, hyperglycaemia, dyslipidaemia and chronic disease; 141 primary clinicians have been trained and 3,220 nutrition instructors deployed, with the West Coast New Area enrolling 89,200 residents in nutrition and weight management.

中上海四院鹿楠团队发现，糖尿病小鼠接受菌群移植后骨小梁变厚变密，骨吸收与炎症因子回落。机制是肠道乳酸杆菌产乳酸入血，使 T 细胞 MOESIN 蛋白 K72 位点乳酸化增强，激活 TGF-β 信号、促 Treg 抑 Th17；用抗体封闭该位点或噬菌体清除该菌，保护作用随即消失。

ENA team led by Lu Nan at Shanghai Fourth People's Hospital found that diabetic mice receiving faecal microbiota transplantation grew thicker, denser trabecular bone while bone-resorption and inflammatory markers fell. Gut lactobacilli produce lactate that enters the blood and boosts lactylation of MOESIN at lysine 72 in T cells, strengthening TGF-beta signalling, expanding Tregs and restraining Th17. Blocking that site with an antibody, or clearing the strain with phages, abolished the protection.

中团队平行分析肝癌患者粪便与肝内微生物组，发现肠道病原共生菌与肝内菌群的相似度升高，脆弱拟杆菌与梭形杆菌富集，且肝内菌群在正常区、边界区、肿瘤区分布不均。患者粪菌移植与单菌定植均能破坏肠屏障、提高肝内菌载并促癌，机制为细菌烯醇化酶结合肝癌细胞波形蛋白。

ENParallel analysis of stool and intrahepatic microbiomes in liver cancer patients showed greater gut-liver microbial similarity, enrichment of Bacteroides fragilis and Fusobacterium spp., and uneven bacterial distribution across normal, boundary and tumour regions. Faecal transfer from patients, or colonization with the single species, breached the gut barrier, raised hepatic bacterial load and promoted tumours; bacterial enolase binding vimentin on hepatoma cells carries the signal.

中广州中医药大学第四临床医学院 63 人对照研究（《营养素》）：产后抑郁者粪便中 Faecalibacterium、Akkermansia 减少，Ralstonia 与 Fusobacterium 增多，血清溶血磷脂乙醇胺等脂质与神经炎症代谢物同步改变。作者称属探索性发现，不足以推荐具体益生菌。

ENIn a 63-person controlled study in Nutrients, researchers at Guangzhou University of Chinese Medicine found that women with postpartum depression had fewer Faecalibacterium and Akkermansia, more Ralstonia and Fusobacterium, and altered serum metabolites including lysophosphatidylethanolamine linked to neuroprotection and lipid metabolism. The authors stress the findings are exploratory and do not yet justify recommending a specific probiotic or supplement.

中研究发现饥饿时 DOT1L 部分转入胞质，甲基化核糖体蛋白 RPL12 的 K41 与 K48，形成供自噬体识别的「eat-me」信号。破坏这两个位点的果蝇核糖体自噬受抑，出现发育异常、运动能力下降加快与寿命缩短；老年期恢复 Gpp 表达可改善运动与应激抵抗。寿命证据仅来自果蝇。

ENUnder starvation, part of DOT1L moves into the cytoplasm and methylates ribosomal protein RPL12 at K41 and K48, creating an eat-me mark that autophagosomes recognise. Flies with both sites mutated showed suppressed ribosome autophagy, developmental defects, faster age-related decline in climbing ability and shorter lifespan; restoring Gpp expression in old flies improved mobility and stress resistance. Lifespan evidence comes only from Drosophila.

中密歇根大学团队轮换雷帕霉素、阿卡波糖、卡格列净、17α-雌二醇与热量限制五种延寿干预，用 AI 在 35 次测试中有 33 次凭代谢特征认出处理组。共同点是脑与血中麦角硫因升高，它也是唯一在两种以上组织进入顶级标志物的分子。研究者强调目前无因果证据。

ENA University of Michigan team rotated mice through rapamycin, acarbose, canagliflozin, 17-alpha-estradiol and caloric restriction, then used AI to identify which intervention a mouse had received from its metabolic profile, succeeding in 33 of 35 tests. Ergothioneine rose in brain and blood under all five and was the only molecule ranked a top marker in more than two tissues. The authors stress there is no causal evidence yet.

中研究在菌群代谢物中鉴定出 N-甲基烟酰胺（N-MNA），主要由鼠李糖乳酪杆菌 GG、活泼瘤胃球菌等在厌氧条件下产生。氘标记显示人结肠上皮细胞 3 小时内即摄取，24 小时内由其合成的 NAD 占总池 21.8%，并绕开 NAMPT 走普赖斯—汉德勒途径；结肠炎模型中可减轻炎症、保护肠屏障。

ENResearchers identified N-methylnicotinamide (N-MNA) among microbial metabolites, produced mainly by Lacticaseibacillus rhamnosus GG and Ruminococcus gnavus under anaerobic conditions. Deuterium labelling showed human colonic epithelial cells take it up within three hours and make 21.8% of the total NAD pool from it within 24 hours, bypassing NAMPT via the Preiss-Handler pathway. In colitis models it reduced inflammation and protected the barrier.

中日本 65 岁以上人口占 29.6%，百岁老人达 107,677 人。森永 12 周试验显示，含长双歧杆菌 BB536 的酸奶使 50 岁以上超重男性 DunedinPACE 衰老速度慢 2.2%；三菱瓦斯化学把 20 毫克 PQQ 做成清澄饮料与软糖；日本自噬联盟已认证多款宣称激活自噬的补剂。

ENWith 29.6% of Japanese aged 65 or older and a record 107,677 centenarians, the healthy-longevity market is widening beyond classic anti-ageing ingredients. A 12-week Morinaga trial found yogurt with Bifidobacterium longum BB536 slowed the DunedinPACE pace of ageing by 2.2% in overweight men over 50. Mitsubishi Gas Chemical now puts 20 mg of PQQ into clear drinks and gummies, and the Japan Autophagy Consortium certifies supplements claiming autophagy activation.

中文章梳理炎症性衰老机制：衰老细胞经 SASP 释放 IL-6、IL-1β、TNF-α，CXCL9、CXCL10、CCL11 与 IL-18 同表观遗传年龄加速、多病共存相关。INSPIRE 队列 970 人随访 3 年显示，炎症年龄时钟的预测力有限，仍需结合步速、肌力、认知与衰弱程度判断个体状态。

ENThe review traces how senescent cells release IL-6, IL-1beta and TNF-alpha through SASP, while CXCL9, CXCL10, CCL11 and IL-18 track with epigenetic age acceleration and multimorbidity. In the 970-person, three-year INSPIRE cohort, an inflammatory age clock predicted outcomes only modestly, so the authors argue it cannot replace clinical assessment combining gait speed, muscle strength, cognition and frailty.

中Min Vitamix 用生活方式问卷加血液检测定制维生素矿物质，标准配方最多 33 种、定制配方最多 80 种活性成分，可按微克调配并随复测改剂量。16 名 18—33 岁女性三个月研究中 11 人完成，维 D 与叶酸显著上升、LDL 下降；样本小且夏季日照是混杂因素。

ENMin Vitamix builds vitamin and mineral formulas from a lifestyle questionnaire plus blood tests, using up to 33 actives in its standard line and 80 in bespoke versions, adjustable by the microgram and revised after retesting. In a three-month study of 16 women aged 18 to 33, 11 completed, with significant rises in vitamin D and folate and a fall in LDL; the sample is small and summer sun exposure is a confounder.

中德州农工 AgriLife 团队总结数十年研究：膳食纤维与特定多不饱和脂肪同食时效果超过两者相加，通过铁死亡清除结肠癌干细胞；单吃纤维或鱼油只走凋亡通路，不出现铁死亡。研究者称这为高风险人群的整食干预提供依据，但目前证据仍来自临床前模型。

ENTexas A&M AgriLife researchers summarize decades of work showing that dietary fiber plus selected polyunsaturated fats produces more than additive effects, killing colorectal cancer stem cells through ferroptosis. Fiber or fish oil alone triggers apoptosis instead, and ferroptosis appears only when both are consumed. The team frames this as a whole-food prevention strategy, though the evidence remains preclinical.

中国家卫健委发布 2026 年版《成人脑卒中食养指南》《成人骨质疏松症食养指南》《成人肌少症食养指南》，按地区与季节给出食养参考，并针对「千金难买老来瘦」「只吃素就养生」等观念纠偏。评论认为官方指南把健康关口前移到日常饮食，有助应对老龄化与慢病高发。

ENThe National Health Commission released 2026 dietary-therapy guidelines for adults with stroke, osteoporosis and sarcopenia, offering regional and seasonal food guidance and correcting beliefs such as thinner is always healthier in old age or that a vegetarian diet alone preserves health. Commentary argues official guidance moves prevention into daily eating, addressing ageing and rising chronic disease.

中麦肯锡调查美英德中逾万人，全球健康市场约 2.7 万亿美元。美国消费者选品时效果与价格并列首位，高支出人群更看效果与品质，清晰成分标签进入前五考量。35% 的 GLP-1 使用者增加蛋白摄入、19% 加用补充剂；约 40% 消费者在长寿、心理与行动力上仍感需求未被满足。

ENMcKinsey surveyed more than 10,000 consumers in the US, UK, Germany and China and values the global wellness market at about 2.7 trillion dollars. US shoppers now rank effectiveness level with price, heavy spenders weigh effectiveness and quality above cost, and clear ingredient labelling is a top-five consideration. Among GLP-1 users, 35% raised protein intake and 19% added supplements; around 40% still report unmet needs in longevity, mental health and mobility.

中马斯特里赫特大学 Schurgers 报告 VitaK-CAC：180 例冠心病患者随机接受 MK-7 360 微克或安慰剂，150 人完成两年。MK-7 组冠脉钙化评分增加 49 分、安慰剂 69 分，增幅低 29%，钙质量累积低约 42%。研究未设心血管事件终点。

ENPresenting at SupplySide Global, Maastricht University's Leon Schurgers reported the VitaK-CAC trial: 180 patients with coronary artery disease were randomized to 360 mcg MK-7 daily or placebo, and 150 completed two years. Calcium scores rose 49 points with MK-7 versus 69 with placebo, a 29% lower increase, while calcium mass accumulation was about 42% lower and dp-ucMGP rises were blunted. The trial was not powered for clinical events.

中超级厄尔尼诺使中东太平洋海表温度异常超过 3℃，秘鲁生产部取消第二季鳀鱼捕捞，第一季也提前结束、仅完成配额 25%。GOED 呼吁品牌多元化 EPA 与 DHA 来源。2023 年同类事件曾把原料价从每公斤 4.48 美元推到 11.12 美元，SPINS 称零售端通常滞后 12—18 个月。

ENA super El Nino pushed tropical Pacific sea surface temperatures more than 3 degrees Celsius above normal, prompting Peru's PRODUCE to cancel the second anchoveta season after closing the first early with only 25% of quota caught. GOED urges brands to diversify EPA and DHA sources. When a full season was cancelled in 2023, raw material prices jumped from 4.48 to 11.12 dollars per kilogram, though SPINS says retail lags by 12 to 18 months.

中11 月 6 日，MitoQ 与一龄医学技术集团在进博会签署健康老龄化合作，围绕细胞健康构建检测、个性化方案到持续追踪的服务体系。cell essentials 系列海洋岩藻黄素、雌马酚、三重镁三款新品亚洲首发；核心成分 MitoQ Mitoquinol 获 TGA 纳入澳洲许可成分清单。

ENOn November 6 at the China International Import Expo, New Zealand cell-health brand MitoQ signed a healthy-ageing partnership with Yiling Medical Technology Group, extending its China business from products to a service chain of testing, personalized protocols and follow-up. Three cell essentials products debuted in Asia: fucoxanthin, equol and a triple-magnesium formula. Its MitoQ Mitoquinol ingredient was also added to Australia's TGA permitted ingredient list for listed supplements.

中澳大利亚南十字星大学获盖茨基金会 18 个月资助，用破囊壶菌精密发酵生产无鱼源 omega-3，试图以农业与食品副产物（如生物柴油副产甘油）替代昂贵碳源，目标把培养成本降低至少 50%，让中低收入国家的孕妇与婴儿用得起 DHA，并减少对野生捕捞的依赖。

ENSouthern Cross University in Australia has an 18-month Gates Foundation grant to produce fish-free omega-3 by precision fermentation of thraustochytrids. The team is testing agricultural and food-processing residues, such as glycerol from biodiesel, as cheap fermentation feedstocks, aiming to cut culture costs by at least 50% so pregnant women and infants in low- and middle-income countries can afford DHA while reducing reliance on wild catch.

中长沙市卫健委 11 月 10 日发布会介绍，居民健康素养水平达 37.97%，十四五期间提升 12.16 个百分点。下一步从优质科普供给、健康支持环境、健康管理服务等五方面推进：依托体重管理门诊、健康步道与营养健康食堂，并以减盐减油为切口做慢病早筛与个性化膳食干预。

ENAt a November 10 briefing, Changsha's health commission said resident health literacy reached 37.97%, up 12.16 percentage points during the 14th Five-Year Plan. Five next steps cover better science communication, supportive environments and upgraded management services, leaning on weight-management clinics, walking trails and nutrition-standard canteens, with salt and oil reduction as the entry point for early screening and personalized dietary advice.

中11 月 10 日，国家卫健委人口文化与基层健康中心在北京举办 2026 年基层卫生健康高质量发展大会，发布 18 个「家医签约·群众有感」推荐案例。秭归按 1+4+N 模式组建 131 支团队覆盖 12 个乡镇，推出基础包、慢病管理包与中医康养包，并对慢病患者实行红黄绿三色分级管理。

ENOn November 10 the National Health Commission's population culture and primary-health center held its 2026 conference in Beijing, releasing 18 recommended family-doctor contracting cases. Zigui county formed 131 teams across 12 townships on a 1+4+N model, offering basic, chronic-disease and TCM rehabilitation packages, and sorts chronic patients into red, yellow and green tiers with tiered follow-up.

中五原县以紧密型县域医共体为抓手，在隆兴昌镇 13 个社区建家庭医生工作室，每周五固定驻点；就诊时同时开药物处方与饮食运动健康处方，配复诊提醒和季节防病提示，慢病按红黄绿分级随访。全县重点人群签约率超 95%，慢病规范管理率 85%，高血压与糖尿病控制率 62%、60%。

ENUsing its compact county medical community, Wuyuan set up family-doctor studios in all 13 communities of Longxingchang town, staffed every Friday. Visits now produce both a drug prescription and a diet-and-exercise prescription plus follow-up reminders and seasonal advice, and chronic patients are followed up by red-yellow-green tier. Priority-group contracting exceeds 95%, standardized management reaches 85%, and hypertension and diabetes control rates are 62% and 60%.

中系列报道梳理三地路径：广东实施「四个一万」基层全民健身计划，东莞南城、深圳侨香落地医师、运动处方师与健康管理师组团服务；四川把体卫融合写入新修订的《四川省体育条例》，首批 35 家医疗机构试点，推评估、筛查、测试、方案、跟踪全链条；上海聚焦社区与老年群体。

ENA series reviewing ten years of sport-health integration compares three paths. Guangdong runs a four-ten-thousand primary-level fitness plan, with Dongguan and Shenzhen piloting teams of physicians, exercise prescribers and health managers. Sichuan wrote integration into its revised sports regulation, starting with 35 medical institutions and a full chain from assessment and screening to testing, prescription and follow-up. Shanghai focuses on communities and older adults.