全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中卫健委明确将统筹推进老年营养标准体系建设，已发布《老年营养补充食品》国标及《老年人膳食指导》《老年人营养不良风险评估》等行业标准，并推动适老食品深度融入社区养老服务体系，开展老年营养改善专项行动与科普，引导市场主体研发适配老年人生理特点的营养健康食品。

ENThe National Health Commission said it will coordinate the development of an elderly nutrition standards system. It has already issued the national standard for "Nutritional Supplementary Foods for the Elderly" along with industry standards such as "Dietary Guidance for the Elderly" and "Malnutrition Risk Assessment for the Elderly." It will further integrate senior-friendly foods into community eldercare services, run dedicated elderly nutrition improvement campaigns and public education, and guide market players toward nutritional health foods adapted to older adults' physiology.

中研究团队证实纤维素拟杆菌（Bacteroides cellulosilyticus）及其代谢产物 2-羟基苯乙酸（2HPAA）通过 PPARγ-CD36 通路双重调控肝脏脂代谢，减轻肝细胞脂质蓄积、改善 MASLD；并依托 42 名受试者 30 天远洋航行纵向队列验证极端环境应激下调该菌、诱发代谢紊乱，为营养干预与防护策略提供理论支撑。

ENThe team showed that Bacteroides cellulosilyticus and its metabolite 2-hydroxyphenylacetic acid (2HPAA) dually regulate hepatic lipid metabolism through the PPARγ–CD36 pathway, reducing lipid accumulation in hepatocytes and improving MASLD. A 30-day longitudinal cohort of 42 subjects on an ocean voyage further verified that extreme environmental stress down-regulates this bacterium and induces metabolic disturbance, providing a theoretical basis for nutritional intervention and protective strategies.

中综述系统梳理「肠道菌群-炎症衰老轴」在老年心血管代谢疾病中的作用：随龄有益菌（双歧杆菌、普拉梭菌）减少、促炎菌扩张导致肠漏与代谢内毒素血症，驱动胰岛素抵抗与血管损伤；地中海/绿色地中海/植物基饮食与间歇性禁食可重塑菌群、降低炎症基调，并探讨基于个体菌群的精准营养与下一代益生菌等转化路径。

ENThe review systematically examines the gut microbiota–inflammaging axis in cardiometabolic disease among older adults: age-related depletion of beneficial bacteria (Bifidobacterium, Faecalibacterium prausnitzii) and expansion of pro-inflammatory taxa cause gut permeability and metabolic endotoxemia, driving insulin resistance and vascular injury. Mediterranean, green-Mediterranean and plant-based diets plus intermittent fasting can remodel the microbiota and lower inflammatory tone. Translational paths such as microbiota-guided precision nutrition and next-generation probiotics are also discussed.

中综述指出肠道菌群及其代谢物（SCFAs、TMAO 等）深度参与代谢、神经退行、心血管与胃肠疾病，微生物酶还能改变药物代谢、解释个体治疗反应差异；作者主张以 FMT、测序选配个性化益生菌、益生元纤维与多酚饮食等工具，将临床实践从「治疗后菌群失调」前移到「预防性维持菌群稳态」，并融入个性化医学。

ENThe review notes that the gut microbiota and its metabolites (SCFAs, TMAO and others) are deeply involved in metabolic, neurodegenerative, cardiovascular and gastrointestinal disease, and that microbial enzymes can alter drug metabolism, helping explain inter-individual differences in treatment response. The authors advocate FMT, sequencing-guided personalized probiotics, prebiotic fiber and polyphenol-rich diets to shift practice from "treating dysbiosis after the fact" toward "preventively maintaining microbial homeostasis" within personalized medicine.

中纽约大学格罗斯曼医学院与克利夫兰大学医院团队在《细胞》发表：长期热量限制（减少 30% 热量）在全基因组范围显著降低老龄小鼠多组织体细胞突变负荷——肝脏整体降 29%、纯化肝细胞降 39%、小脑神经元亦呈下降趋势，并降低年龄相关突变特征 SBS5/SBS-A 积累，确立「基因组完整性」为可经膳食与代谢干预调控的衰老轴。

ENA team from NYU Grossman School of Medicine and University Hospitals Cleveland reported in Cell that long-term caloric restriction (30% fewer calories) significantly lowers multi-tissue somatic mutation burden genome-wide in aged mice — 29% lower overall in liver, 39% lower in purified hepatocytes, with a downward trend in cerebellar neurons. It also reduced accumulation of the age-related mutational signatures SBS5/SBS-A, establishing genome integrity as an aging axis modifiable by dietary and metabolic intervention.

中上海交通大学吴紫云团队在论坛上分享：用 30% 膳食纤维替换宏量营养素可模拟热量限制效果，显著改善小鼠记忆、代谢并延长寿命；同时钾元素可延长线虫寿命，且神经系统能快速感知低钾环境诱导表皮应激反应。她强调「衰老是疾病因素，营养过剩需靠均衡而非盲目少吃解决」。

ENWu Ziyun's team at Shanghai Jiao Tong University reported at the forum that replacing macronutrients with 30% dietary fiber mimics caloric restriction, significantly improving memory and metabolism and extending lifespan in mice. Potassium also extended C. elegans lifespan, and the nervous system can rapidly sense a low-potassium environment to induce epidermal stress responses. She stressed that "aging is a disease factor, and nutrient excess should be addressed through balance rather than blind undereating."

中诺华生物医学研究衰老与再生医学全球负责人 Jimmy Elliott 在论坛指出，衰老由多种疾病共同驱动，单纯组织再生或增肌不足以持久改善功能；诺华已构建 AI 驱动的靶点识别平台，整合 3.7 万+ 样本纵向数据，探索恢复组织与功能、降低年龄相关疾病风险的新型疗法。

ENJimmy Elliott, global head of aging and regenerative medicine at Novartis Biomedical Research, noted at the forum that aging is driven by multiple diseases together and that tissue regeneration or muscle building alone is insufficient for durable functional improvement. Novartis has built an AI-driven target discovery platform integrating longitudinal data from more than 37,000 samples to explore novel therapies that restore tissue and function and lower the risk of age-related disease.

中基因泰克首席研究员 Heinrich Jasper 分享其团队利用果蝇和小鼠模型揭示干细胞衰老与再生的分子机制：非经典 Wnt 信号分子 sPtk7 在年轻时会短暂激活、促进损伤修复，但衰老后持续释放反而阻碍干细胞分化、破坏机体再生能力，为干预衰老相关再生能力下降提供新靶点。

ENHeinrich Jasper, principal investigator at Genentech, shared how his team used Drosophila and mouse models to reveal the molecular mechanisms of stem cell aging and regeneration: the non-canonical Wnt signaling molecule sPtk7 is transiently activated in youth to promote injury repair, but with age its continuous release instead blocks stem cell differentiation and undermines the body's regenerative capacity — offering a new target for age-related regenerative decline.

中一项新研究聚焦母体肠道微生态与婴儿健康的关联，提示孕期及哺乳期母体菌群结构可能影响子代早期免疫、代谢与发育轨迹，为基于母婴菌群特征的个性化营养干预与益生菌策略提供了新证据方向。

ENA new study examines the link between the maternal gut microecosystem and infant health, suggesting that maternal microbiota composition during pregnancy and lactation may shape the offspring's early immune, metabolic and developmental trajectories. It points to new evidence directions for personalized nutritional interventions and probiotic strategies based on mother–infant microbiota characteristics.

中综述综合啮齿类粪菌移植、人体观察队列与早期临床试验证据，指出肌少症人群 SCFA 产生菌减少 25%–40%，年轻供体粪菌可恢复老年/肌少小鼠肌量与力量；丁酸经 SIRT1 激活 PGC-1α 驱动线粒体生成，而菌群失调 LPS 同时促肌萎缩与脑内促炎小胶质细胞活化，作者主张以个体菌群分型指导膳食与益生菌干预，作为预防「认知衰弱」的下一步。

ENThe review synthesizes rodent FMT studies, human observational cohorts and early clinical trials, noting that SCFA-producing bacteria are 25%–40% lower in people with sarcopenia and that fecal microbiota from young donors can restore muscle mass and strength in aged or sarcopenic mice. Butyrate drives mitochondrial biogenesis via SIRT1 activation of PGC-1α, while dysbiosis-associated LPS simultaneously promotes muscle atrophy and pro-inflammatory microglial activation in the brain. The authors advocate microbiota stratification to guide dietary and probiotic interventions as the next step in preventing cognitive frailty.

中文章探讨表观遗传时钟作为长寿与精准营养干预生物标志物的潜力，同时提醒：不同时钟（DNA 甲基化、转录组、蛋白质、影像、微生物组等）测的不一定是同一件事，哪一种干预对应驱动哪一种「针」仍需更多头对头验证，方能将时钟用于真正的分层试验与个性化方案。

ENThe article explores the potential of epigenetic clocks as biomarkers for longevity and precision-nutrition interventions, while cautioning that different clocks (DNA methylation, transcriptome, proteome, imaging, microbiome and more) may not measure the same thing. Which intervention moves which specific needle still requires more head-to-head validation before clocks can support genuine stratification trials and personalized programs.

中由 Buchinger Wilhelmi 联合 King's College London、莱顿大学医学中心等开展的随机对照试验（75 人）于 9 月启动，探究在 10±4 天 Buchinger 禁食方案中补充玉米来源抗性淀粉 IV 型，能否经肠道菌群（如产丁酸菌 Oscillibacter）协同改善血糖、酮体与菌群代谢输出，首次在人体验证「禁食+纤维」的协同概念。

ENA randomized controlled trial (n=75) run by Buchinger Wilhelmi with King's College London and Leiden University Medical Center launched in September to test whether supplementing a 10±4-day Buchinger fasting program with maize-derived type IV resistant starch can synergistically improve blood glucose, ketone bodies and microbial metabolic output via gut bacteria such as the butyrate producer Oscillibacter. It is the first human test of the "fasting + fiber" synergy concept.

中一项针对 184 名乳房切除术女性的研究表明，维生素 D 缺乏患者术后经历中重度疼痛的概率是充足者的约 3 倍，提示低维生素 D 水平会加重恢复期的疼痛体验，为围手术期营养评估与维生素 D 管理提供了实证依据。

ENA study of 184 women who underwent mastectomy found that those with vitamin D deficiency were about three times more likely to experience moderate-to-severe postoperative pain than those with adequate levels, suggesting low vitamin D worsens the pain experience during recovery. It provides empirical support for perioperative nutritional assessment and vitamin D management.

中BRAND'S 将人参以凝胶（jelly）新剂型推出，面向高压、快节奏的年轻职场人群，主打方便携带与即食的每日精力管理；反映功能食品正以「趣味化、便捷化剂型」切入都市白领的抗疲劳与日常营养补充场景。

ENBRAND'S is launching ginseng in a new jelly format aimed at high-pressure, fast-paced young professionals, emphasizing portability and ready-to-eat daily energy management. It reflects how functional foods are entering urban white-collar anti-fatigue and daily nutrition scenarios through playful, convenient dosage forms.

中一项在健康成人中开展的随机对照试验显示，Dose for Cholesterol 这类植物/营养素复合降脂补充剂可带来具有统计学意义的血脂改善，延续了「以循证 RCT 支撑功能性降脂补充剂」的行业趋势，为血脂边缘升高人群提供了非处方辅助选项。

ENA randomized controlled trial in healthy adults showed that a botanical and nutrient combination lipid-lowering supplement such as Dose for Cholesterol produced statistically significant improvements in blood lipids. It continues the industry trend of supporting functional lipid-lowering supplements with evidence-based RCTs, offering an over-the-counter adjunct option for people with borderline-elevated lipids.

中文章指出围绝经期（perimenopause）正从笼统的「女性健康/更年期」中剥离为独立品类，品牌围绕荷尔蒙平衡、情绪、睡眠与骨骼等痛点开发专属配方；这与 2026 年「女性健康精细化、按生命阶段分场景」的营养趋势相呼应。

ENThe article notes that perimenopause is separating from the broad women's health and menopause bucket into its own category, with brands developing dedicated formulas around hormonal balance, mood, sleep and bone health. This echoes the 2026 nutrition trend of refined women's health segmented by life stage and scenario.

中在国新办「十五五」发布会上，雷海潮提出慢病防控「六件事」：控油盐糖（盐≤5g、油≤30g、添加糖≤25g/天）、每小时起身活动 5–10 分钟、理性看待网络科普、贯彻「健康第一」教育理念、单位社区共筑健康防线；并明确「十五五」目标居民健康素养力争达 40%、2030 年人均预期寿命达 80 岁，标志健康管理上升为国家战略。

ENAt the State Council Information Office briefing on the 15th Five-Year Plan, Lei Haichao outlined six priorities for chronic disease prevention: control oil, salt and sugar (salt ≤5 g, oil ≤30 g, added sugar ≤25 g per day); stand up and move for 5–10 minutes every hour; approach online health content rationally; implement a health-first educational philosophy; and have workplaces and communities jointly build health defenses. He set targets of 40% resident health literacy during the 15th Five-Year Plan and an average life expectancy of 80 years by 2030, marking health management's rise to a national strategy.

中华为第三代腕部动态血压记录仪 WATCH D3（2988 元起）开启预售，首创「轻扰动态血压研究」——每日仅 7 次充气即获日间/夜间/24h 均值，已获二类医疗器械注册证与计量器具型式批准；配合 ECG、睡眠呼吸暂停、高尿酸/血糖研究等，标志腕上设备加速从消费电子迈向「医疗级硬件」。

ENHuawei's third-generation wrist ambulatory blood pressure recorder, WATCH D3 (from ¥2,988), has opened pre-orders with an industry-first low-disturbance ambulatory blood pressure study: only seven inflations per day yield daytime, nighttime and 24-hour averages. It has obtained Class II medical device registration and metrological instrument type approval. Alongside ECG, sleep apnea, high uric acid and blood glucose research, it signals wrist devices accelerating from consumer electronics toward medical-grade hardware.

中JDDiscovery-2026 上京东健康发布京医千询 3.0（原生 3D 影像理解、MedCode 可溯源代码执行、长程任务协作）与医生 AI 工作台 MedWork，并将 App 升级为「国民首席 AI 健康管家」；强调以「AI+硬件+服务」闭环把健康管理从「测一次」推向「管到底」，覆盖院外体重管理、基层医生辅诊与慢病随访。

ENAt JDDiscovery-2026, JD Health launched Jingyi Qianxun 3.0 (native 3D imaging understanding, MedCode traceable code execution, long-horizon task collaboration) and the physician AI workspace MedWork, upgrading its app into a national chief AI health steward. It emphasizes an AI + hardware + services loop that moves health management from measuring once to managing all the way through, covering out-of-hospital weight management, primary-care decision support and chronic disease follow-up.

中荣耀在开发者大会宣布运动健康战略升级，新一代旗舰荣耀手表 6 Pro（9/28 发布）行业首发「心脏停搏预警」：经双波长识别、多波长交叉核验与用户行为识别四阶段研判，一旦检测到心脏骤停即自动触发紧急呼救并声光提醒，实现从「预警」到「急救」的主动健康守护闭环。

ENAt its developer conference, Honor announced an upgrade to its sports and health strategy. The new flagship Honor Watch 6 Pro (launching Sept 28) is the industry's first with cardiac arrest warning: through a four-stage process of dual-wavelength detection, multi-wavelength cross-verification and user behavior recognition, it automatically triggers emergency calls with audible and visual alerts once cardiac arrest is detected, closing the loop from early warning to emergency rescue.