全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中俄勒冈健康与科学大学团队在《自然·代谢》发表首个针对亨廷顿病的限时进食临床研究：20名早期患者将每日进食限制在6—8小时窗口并坚持12周，体重与瘦体重保持稳定，综合统一亨廷顿病评定量表平均改善0.5分（该评分通常每年下降约1分），神经丝轻链平均下降13%，血细胞线粒体活性多项指标改善。团队正筹备更大规模随机对照试验。

ENAn OHSU-led team published the first clinical study of time-restricted eating in Huntington's disease in Nature Metabolism: 20 early-stage patients limited eating to a 6–8 hour daily window for 12 weeks. They maintained weight and lean mass, improved 0.5 points on the composite UHDRS (which typically declines ~1 point per year), saw neurofilament light fall 13%, and showed improved mitochondrial activity in blood cells. A larger randomized trial is being planned.

中中山大学附属第六医院苏明丽团队联合深圳大学第一附属医院等在《Bioactive Materials》报道水响应型可注射凝胶Alg-NHS@αLA：接触湿润结肠黏膜后迅速原位成胶，湿态黏附强度达72.9千帕，携带粪菌在结肠驻留超72小时；小鼠结肠炎模型中修复紧密连接、驱动巨噬细胞M2极化并恢复短链脂肪酸水平，并已在猪肠镜模型验证，为提升粪菌移植定植效率提供新材料平台。

ENA team led by Su Mingli at Sun Yat-sen University's Sixth Affiliated Hospital reported in Bioactive Materials a water-responsive injectable hydrogel (Alg-NHS@αLA) that gels in situ on wet colonic mucosa, achieving 72.9 kPa wet adhesion and over 72 hours of fecal-microbiota retention. In a mouse colitis model it repaired tight junctions, drove M2 macrophage polarization and restored short-chain fatty acids; porcine endoscopic delivery was validated, offering a new materials platform for FMT.

中中国疾控中心任志鸿、徐建国团队联合山西白求恩医院在《Advanced Science》揭示植物乳植杆菌GUANKE缓解过敏性哮喘的肠-肺轴机制：菌株重塑肠道菌群并恢复色氨酸代谢物吲哚-3-乙酸（IAA）水平，IAA经抑制STAT3-Jag1-Notch4信号轴限制单核前体向肺部树突细胞分化；哮喘患者血清IAA亦显著低于健康人，为不依赖抗生素的微生态干预提供新靶点。

ENA China CDC team led by Ren Zhihong and Xu Jianguo, with Shanxi Bethune Hospital, reported in Advanced Science how Lactiplantibacillus plantarum GUANKE eases allergic asthma: the strain remodels gut microbiota and restores tryptophan metabolite indole-3-acetic acid (IAA), which limits monocyte-to-dendritic-cell differentiation via the STAT3–Jag1–Notch4 axis. Asthma patients also showed lower serum IAA, suggesting a microbiome-based, antibiotic-free intervention target.

中“人是被肠胃菌群控制的高达”话题近日引发热议。中山大学附属第六医院陈俊榕表示，肠道菌群与人体是双向调控：菌群经肠脑轴参与食欲、情绪与免疫信号，但大脑认知、激素与环境同样反向塑造菌群。她提醒，粪菌移植须在正规医疗机构开展，健康人无需常规做菌群检测，养护菌群应保证每日25—30克膳食纤维、避免滥用抗生素与盲目“清肠排毒”。

ENA viral topic claimed gut microbes 'pilot' the human body. Chen Junrong of Sun Yat-sen University's Sixth Affiliated Hospital clarified that gut microbiota and the body regulate each other: microbes shape appetite, mood and immunity via the gut–brain axis, while cognition, hormones and environment reshape microbes. FMT must be done in licensed institutions; healthy people need no routine microbiome testing; 25–30 g of daily fiber and avoiding antibiotic overuse remain the basics.

中UCLA Health团队发表于《柳叶刀·健康长寿》的随机对照试验二次分析显示：近100名60岁以上失眠老人接受失眠认知行为疗法（CBT-I）后，失眠缓解几率约为睡眠教育对照组的3倍，且DunedinPACE表观遗传时钟测得的衰老速度显著放缓，平均每年慢约2%。研究者指出，睡眠是继运动与饮食之后又一个可干预的衰老调节靶点，但结论仍需多中心研究验证。

ENA secondary analysis of an RCT published in The Lancet Healthy Longevity found that among nearly 100 adults aged 60+, cognitive behavioral therapy for insomnia (CBT-I) tripled the odds of remission versus sleep education and significantly slowed biological aging on the DunedinPACE epigenetic clock — about 2% slower aging per year. Sleep joins exercise and diet as a modifiable target, though multisite replication is needed.

中加州大学圣塔芭芭拉分校团队9月22日在《自然·医学》发表血液蛋白组研究：绝经伴随16种蛋白显著升高，涵盖炎症、突触、代谢与阿尔茨海默病相关通路；由此构建的“绝经蛋白组评分”与更快的认知衰退、更高的痴呆风险相关，并在超1.1万人的四个独立队列中获得验证。蛋白变化更多与FSH等激素相关而非实际年龄，提示围绝经期是女性脑健康干预的关键窗口。

ENA UC Santa Barbara team reported in Nature Medicine that menopause is accompanied by significant elevations of 16 blood proteins spanning inflammation, synaptic, metabolic and Alzheimer's-related pathways. A 'menopause proteomic score' built from these proteins tracked faster cognitive decline and higher dementia risk across four cohorts totaling 11,000+ participants. Changes tracked hormones like FSH more than age, framing perimenopause as a key window for women's brain health.

中第二届国际长寿大会9月24日在罗马尼亚布加勒斯特国家图书馆举行，主题为“从科学到医学实践”。西班牙CNIO端粒专家Maria Blasco、哈佛医学院部分细胞重编程研究者、KAUST表观遗传学者Valerio Orlando等来自欧美、以色列、印度与沙特的专家，围绕健康寿命延长、端粒与表观遗传、再生医学及长寿干预的预防、诊断与个性化落地路径展开研讨。

ENThe 2nd International Longevity Congress opened September 24 in Bucharest under the theme 'From Science to Medical Practice.' Speakers including telomere biologist Maria Blasco (CNIO), Harvard partial-reprogramming researchers and KAUST epigeneticist Valerio Orlando discussed extending healthspan, epigenetics and regenerative medicine, and how to turn aging biology into prevention, diagnostics and personalized interventions.

中全球长寿联合会9月22日刊文指出，康养与长寿正重塑酒店与度假地产投资逻辑：个性化健康体验、医学检测与长寿干预服务被嵌入高端住宿场景，催生“长寿养生度假”新业态。分析认为，把临床级健康管理搬到旅行场景，将成为长寿经济从诊所走向大众消费的重要通道，也为功能医学与精准营养服务提供新的落地入口。

ENThe Global Longevity Federation reported that wellness and longevity are reshaping hospitality investment: personalized health experiences, medical testing and longevity interventions are being embedded into high-end resorts, creating a new 'longevity hospitality' category. Moving clinic-grade health management into travel settings could bring the longevity economy from clinics to mass consumers, opening new channels for functional medicine and precision nutrition services.

中重庆医科大学第二附属医院团队在《Journal of Functional Foods》报道，2型糖尿病小鼠经本土AKK菌（Akkermansia muciniphila ONE）干预后，总胆固醇下降49.22%、甘油三酯下降25.87%、高密度脂蛋白升高47.77%，肝脏脂滴明显减少，机制与AMPK/PPAR-α信号通路调控相关。证据仍来自动物实验，但显示AKK菌研究正从肠道屏障走向全身糖脂代谢干预。

ENA team at Chongqing Medical University's Second Affiliated Hospital reported in Journal of Functional Foods that in type 2 diabetic mice, supplementation with the native strain Akkermansia muciniphila ONE lowered total cholesterol 49.22% and triglycerides 25.87%, raised HDL 47.77% and reduced hepatic lipid droplets, via AMPK/PPAR-α signaling. Evidence remains preclinical, but shows Akkermansia research expanding from gut barrier toward systemic lipid-glucose metabolism.

中发表于《Antioxidants》的意大利记忆门诊92名65岁以上老人横断面研究显示：无轻度认知障碍（MCI）者总多酚、类黄酮与木脂素摄入显著更高；总多酚摄入最高四分位组MCI风险较最低组大幅降低（调整后OR=0.08），橙皮素、柚皮素等与认知评分正相关。但多酚摄入与炎症标志物无稳定关联，提示其认知获益未必经由抗炎通路，仍需前瞻性与干预研究确认。

ENA cross-sectional study of 92 Italians aged 65+ at a memory clinic, published in Antioxidants, found that those without mild cognitive impairment (MCI) reported significantly higher total polyphenol, flavonoid and lignan intake. The top quartile of total polyphenol intake had far lower odds of MCI (adjusted OR 0.08); hesperetin and naringenin correlated with cognition. No consistent link with inflammatory markers emerged, so benefits may not run through anti-inflammatory pathways; prospective trials are needed.

中清华大学程功、王毛团队在《Cell Research》发表研究：营养不良会重塑皮肤菌群结构，使感染动物体表气味释放更吸引蚊虫，从而加剧蚊媒传播效率。研究把宿主营养状态—皮肤微生物—媒介昆虫行为串成完整通路，提示改善人群营养状况可能间接削弱登革热等蚊媒传染病的传播，为“营养干预+传染病防控”的交叉策略提供新证据。

ENA Tsinghua University team led by Cheng Gong and Wang Mao reported in Cell Research that malnutrition reshapes skin microbiota so infected hosts emit odors more attractive to mosquitoes, boosting transmission efficiency. Linking host nutrition, skin microbes and vector behavior in one pathway, the findings suggest improving nutrition could indirectly curb mosquito-borne diseases like dengue — a new cross-strategy of nutrition plus infectious-disease control.

中西班牙植物原料商Monteloeder近日表示，将把增长重心放在代谢健康与“由内而外美容”两大方向：代谢综合征人群扩大与消费者对口服美容方案接受度提升，正带动相应植物提取物与循证配方需求。公司称将以临床验证与数字化个性化方案为差异化抓手，配合品牌方开发面向血糖、体重与皮肤健康的复合产品线。

ENSpanish botanical ingredient maker Monteloeder said its growth will focus on metabolic health and beauty-from-within: expanding metabolic-syndrome populations and rising acceptance of oral beauty solutions are lifting demand for evidence-backed plant extracts. The company plans to differentiate through clinical validation and digital personalization, co-developing product lines targeting blood glucose, weight and skin health.

中NutraIngredients 9月23日报道一项针对老年人的新研究：维生素D与维生素B12“共缺乏”在老年人群并不少见，且可能带来叠加风险——前者关系骨骼肌功能，后者关系神经与造血功能，共缺乏会放大跌倒、贫血与认知下降风险。研究者建议对老年人开展两种营养素的联合筛查并评估联合补充策略，而非单一营养素孤立干预。

ENNew research covered by NutraIngredients shows vitamin D and vitamin B12 co-deficiency is common in older adults and may compound health risks: vitamin D supports musculoskeletal function while B12 supports nerves and hematopoiesis, so combined deficiency can amplify fall, anemia and cognitive-decline risk. Researchers recommend joint screening and combined supplementation strategies for the elderly rather than isolated single-nutrient interventions.

中新西兰补剂品牌Lifestream接受NutraIngredients采访时称，“视力-大脑双重照护”正成为眼部补剂创新的核心驱动：消费者不再只关注黄斑与干眼，而是把眼健康与认知衰退预防合并考量，叶黄素、玉米黄质与Ω-3等成分的复配需求上升。公司表示，面向老年与高强度屏幕人群的产品线将围绕眼-脑轴做循证与宣称升级。

ENNew Zealand supplement brand Lifestream told NutraIngredients that vision–brain dual care is becoming the core innovation driver for eye supplements: consumers now consider eye health together with cognitive-decline prevention, lifting demand for combinations of lutein, zeaxanthin and omega-3s. Product lines for seniors and heavy screen users will build evidence and claims around the eye–brain axis, the company said.

中瑞士原料商Mibelle指出，韩国“由内而外”美容补剂市场持续升温：胶原蛋白、神经酰胺、益生菌与抗氧化成分组合的口服美容产品在年轻消费群体中渗透率不断提高。公司认为，韩国市场对“可证明的机制+成分故事”要求更高，品牌与原料商需要在临床数据、递送技术与可持续来源上同时发力，才能在竞争中立足。

ENSwiss ingredient supplier Mibelle noted South Korea's beauty-from-within market keeps growing: oral beauty products combining collagen, ceramides, probiotics and antioxidants are gaining traction among younger consumers. The company said Korean consumers demand provable mechanisms and strong ingredient stories, so brands and suppliers must invest in clinical data, delivery technology and sustainable sourcing to stay competitive.

中美国补剂品牌Ancient Nutrition向NutraIngredients介绍其“从农场到货架”的再生农业供应链：通过再生耕作种植补剂原料作物并追溯至具体农场，把土壤健康与成分营养密度关联作为卖点。公司称，再生供应链不仅是ESG叙事，也是应对原料掺假与质量波动的品控手段，未来将扩大自有农场与透明溯源标签的覆盖品类。

ENUS supplement brand Ancient Nutrition described its 'farm to shelf' regenerative agriculture supply chain to NutraIngredients: growing ingredient crops via regenerative practices, tracing them to specific farms, and linking soil health to nutrient density as a selling point. The company says regenerative supply is not just an ESG story but a quality-control answer to adulteration and ingredient variability, and it will expand owned farms and transparent sourcing labels.

中央视《新闻联播》9月22日播出“坚持预防为主 守护全民健康”专题：甘肃慢病与高发癌症筛查专项行动已筛查慢病患者440多万人，新发现96万余人全部纳入健康信息系统随访管理；国家免疫规划可预防疾病扩至16种，HPV疫苗今年纳入国家免疫规划，全国已有520多万名13岁适龄女孩完成首剂接种；儿童青少年“五健”行动把健康关口前移到校园。

ENCCTV's Xinwen Lianbo on September 22 highlighted China's prevention-first health strategy: Gansu's chronic disease and cancer screening campaign has covered over 4.4 million people, with 960,000 newly detected patients enrolled in follow-up; the national immunization program now prevents 16 diseases; HPV vaccination was added this year with 5.2+ million 13-year-old girls receiving first doses; and the 'Five Healths' school initiative moves prevention into campuses.

中国家卫生健康委与市场监管总局近日联合发布50项新食品安全国家标准及修改单，覆盖食品中铅污染控制、婴幼儿及学龄前儿童营养补充、牛乳蛋白等与日常饮食健康密切相关的领域。新标准以防风险、保健康、促发展为导向，细化食品安全全链条管控要求，既是消费者健康权益的重要保障，也为企业合规生产与监管执法提供统一“硬标尺”。

ENChina's National Health Commission and the State Administration for Market Regulation jointly issued 50 new national food safety standards and amendments, covering lead contamination control, nutrition supplements for infants and preschool children, milk proteins and other diet-related areas. Oriented toward risk prevention, health protection and development, the standards refine whole-chain food safety management and set a unified yardstick for compliance and enforcement.

中国家卫生健康委9月22日公布《孤独症谱系障碍儿童干预康复指南（2026年版）》，明确目前针对孤独症病因和发病机制的特异性治疗方法仍有限，主要干预方法为康复训练，最佳治疗期为6岁前、越早干预效果越好。指南围绕早期筛查、家庭参与、康复机构规范与转介路径给出系统要求，为基层开展儿童心理行为健康服务提供依据。

ENChina's National Health Commission published the 2026 edition of its intervention and rehabilitation guideline for children with autism spectrum disorder, noting that disease-specific treatments remain limited, rehabilitation training is the mainstay, and the best window is before age six — the earlier the better. The guideline systematizes early screening, family participation, provider standards and referral pathways for grassroots child mental and behavioral health services.

中NutraIngredients 9月23日刊文称，AI正在重塑消费者获取健康与营养信息的方式，营养品牌面临一场“信任测试”：生成式工具放大了伪科学与夸大宣称的传播风险，也带来个性化沟通的新机会。受访行业人士建议，品牌应主动投资循证内容、透明溯源与第三方验证，把“科学可信”作为AI信息生态中的核心竞争资产。

ENAI is reshaping how consumers obtain health and nutrition information, and nutrition brands face a trust test: generative tools amplify the spread of pseudoscience and exaggerated claims while creating new opportunities for personalized communication. Industry voices recommend investing in evidence-based content, transparent sourcing and third-party validation, making scientific credibility the core competitive asset in the AI information ecosystem.