全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中挪威分子诊断公司 Genetic Analysis 宣布其加拿大专利申请获准授权，保护一种体外诊断方法：通过分析肠道菌群组成识别特定细菌模式，筛选更可能对粪菌移植（FMT）治疗产生应答的肠易激综合征（IBS）患者。IBS 影响全球约 5%-10% 人群，约 70% 患者存在菌群失调，该专利将菌群特征从描述失调升级为指导治疗选择，专利保护期延至 2037 年，标志着菌群伴随诊断向个体化治疗决策迈出实质一步。

ENNorwegian molecular diagnostics company Genetic Analysis announced that its Canadian patent application has been allowed, protecting an in vitro diagnostic method that analyzes gut microbiota composition to identify bacterial patterns predicting which irritable bowel syndrome (IBS) patients are more likely to respond to fecal microbiota transplantation (FMT). IBS affects an estimated 5-10% of the global population and about 70% of patients show dysbiosis. The patent elevates microbiota signatures from describing dysbiosis to guiding treatment selection, with protection extending to 2037 — a substantive step toward individualized treatment decisions in microbiome-based companion diagnostics.

中美国德州大学 MD 安德森癌症中心团队在 Cell Reports Medicine 发表粪菌移植（FMT）一线治疗免疫检查点抑制剂相关腹泻和结肠炎（IMDC）的临床数据：13 例患者中 10 例（76.9%）达到临床响应，临床改善中位时间仅 1.5 天；应答者 FMT 后肠道微生物多样性增加，浆细胞、多种 T 细胞亚群等免疫细胞丰度下降。研究提示 FMT 有望从难治性结肠炎的补救方案前移为一线干预选项。

ENResearchers at the University of Texas MD Anderson Cancer Center published clinical data in Cell Reports Medicine on first-line fecal microbiota transplantation (FMT) for immune checkpoint inhibitor-mediated diarrhea and colitis (IMDC): 10 of 13 patients (76.9%) achieved clinical response, with a median time to improvement of just 1.5 days. Responders showed increased gut microbial diversity after FMT and reductions in plasma cells and multiple T-cell subsets. The findings suggest FMT could move from a salvage option for refractory colitis toward first-line intervention.

中陕西师范大学韩彦慧团队在 Gut Microbes（IF 15.3）发表研究，发现真菌细胞外囊泡可重塑鼠李糖乳杆菌的细菌外囊泡，使其增强宿主溶酶体稳态并消退肠道炎症。该工作提示微生物组之间通过囊泡介导的跨界“对话”可以改变益生菌的功能表型，为通过后生元与囊泡工程设计更精准的微生态干预提供了新机制视角，也拓展了功能医学肠道干预的工具箱。

ENA team led by Han Yanhui at Shaanxi Normal University reported in Gut Microbes that fungal extracellular vesicles can reshape bacterial membrane vesicles of Lactobacillus rhamnosus, enhancing host lysosomal homeostasis and resolving intestinal inflammation. The work suggests cross-kingdom vesicle-mediated “dialogue” within the microbiome can alter probiotic functional phenotypes, offering a new mechanistic angle for designing more precise postbiotic and vesicle-engineered interventions and expanding the gut-focused toolkit of functional medicine.

中9 月 24-25 日，第二届 RIKEN–ISM Targeting Microbiota 2026 在东京大学举行，来自 11 个国家的 65 场学术报告覆盖宿主-菌群互作、微生物代谢物、免疫、线粒体、单细胞与株水平方法、精准治疗等前沿方向。贯穿大会的核心之问是：如何从关联走向因果、再从因果走向精准干预。会议提供线上参与通道，为亚洲微生态临床转化研究搭建了重要国际对话平台。

ENOn September 24-25, the 2nd RIKEN–ISM Targeting Microbiota 2026 convened at the University of Tokyo, featuring 65 scientific communications from 11 countries covering host-microbiota interactions, microbial metabolites, immunity, mitochondria, single-cell and strain-level approaches, and precision therapeutics. The running question throughout the meeting: how to move from association to causality — and from causality to precise intervention. Online participation was available, making the event a key international platform for clinical translation of microbiome research in Asia.

中ScienceDaily 报道，一种可清除衰老、受损细胞的局部外用药物帮助老年小鼠皮肤伤口显著加快愈合。治疗似乎重新激活了涉及炎症调控、胶原合成与新血管生成的修复通路，提示senolytic 策略不仅可延缓皮肤老化，还有望用于改善老年人慢性创面、压疮等临床难题。该研究为局部递送的抗衰老干预提供了器官特异性转化范例。

ENScienceDaily reports that a topical drug removing senescent, damaged cells helped older mice heal skin wounds significantly faster. The treatment appeared to reactivate repair pathways involved in inflammation resolution, collagen production and new blood vessel formation, suggesting senolytic strategies may not only slow skin aging but also address clinical problems such as chronic wounds and pressure ulcers in older adults — an organ-specific translational model for locally delivered anti-aging interventions.

中9 月 23-26 日约 1000 名老年医学专家齐聚法兰克福。德国老年医学会主席 Michael Denkinger 会前指出，市售“组织年轻化”肽类等长寿产品的证据仍停留在动物实验，“目前没有任何产品被证明能让人活得更长”；他反对将正常衰老病理化为疾病，同时强调规律运动、均衡饮食、戒烟限酒、定期体检与社会参与才是有临床研究支撑的健康衰老基石。9 月 26 日大会专设“衰老是否是疾病”辩论专场。

ENAbout 1,000 geriatric specialists gathered in Frankfurt on September 23-26. Ahead of the congress, German Geriatrics Society president Michael Denkinger noted that evidence for commercial longevity products such as tissue-rejuvenating peptides remains limited to animal testing — 'there is no product that has shown that it makes humans live longer' — and rejected pathologizing normal aging, while stressing that regular activity, balanced diet, avoiding tobacco and alcohol, checkups and social engagement remain the evidence-based core of healthy aging. A dedicated session titled 'Is aging a disease?' is scheduled for September 26.

中9 月 18-20 日，2026 智慧医学与创新发展大会在深圳光明区召开，北京老年医院承办平行会议“第三届主动健康与临床衰老医学会议”。大会启动 6 项主动健康与衰老医学团体标准，为我国主动健康与衰老医学干预的标准化建设提供支撑；北京老年医院副院长刘小鹏作《人工智能驱动的未来医学革命——“主动健康”医学范式探究与实践路径》主旨报告，并与中关村生命健康产业公司签约共建“医学成果转化促进中心”。

ENOn September 18-20, the 2026 Smart Medicine and Innovation Development Congress convened in Guangming, Shenzhen, with Beijing Geriatric Hospital hosting the parallel '3rd Conference on Proactive Health and Clinical Aging Medicine.' Six group standards on proactive health and aging medicine were officially launched to support standardization of aging interventions in China. Liu Xiaopeng, vice president of the hospital, delivered a keynote on AI-driven proactive health paradigms, and a strategic agreement was signed to jointly build a Medical Achievement Translation Promotion Center with Zhongguancun Life and Health Industry.

中9 月 22 日，和祐国际医院集团长寿抗衰中心在佛山正式开业。中心以健康管理为本，打造“查状态、防意外、调功能、抗衰老”四阶式服务内涵，围绕生物年龄检测、免疫平衡、脑力维护、代谢年轻化等十大抗衰专项建立健康画像与个体化长寿管理方案；专家矩阵覆盖抗衰医学、心血管、免疫、脑科学、功能医学、再生医学与数智化中医等领域，体现长寿医学正加速从概念走向医疗机构的实体化服务闭环。

ENOn September 22, the Longevity and Anti-Aging Center of Heyou International Hospital Group officially opened in Foshan. Anchored in health management, the center offers a four-stage service model — assess status, prevent emergencies, restore function, counter aging — and builds individualized longevity plans around ten anti-aging programs including biological age testing, immune balance, brain maintenance and metabolic rejuvenation. Its expert matrix spans anti-aging medicine, cardiology, immunology, brain science, functional medicine, regenerative medicine and digital TCM, reflecting how longevity medicine is moving from concept to institutionalized clinical service loops.

中刘洪涛团队在 iMeta（IF 44.4）发表研究，揭示膳食纤维的抗肥胖效应可由肠道屎肠球菌源性亮氨酸（leucic acid）介导。该发现把“吃纤维→菌群代谢→宿主获益”的经典链条推进到具体菌株-具体代谢物-具体效应的因果层面，为以菌群代谢物为靶点的精准营养干预提供了新的分子接口，也提示相同膳食纤维在不同肠道菌群背景下的减重效果可能存在个体差异。

ENA team led by Liu Hongtao reported in iMeta (IF 44.4) that the anti-obesity effect of dietary fiber can be mediated by Enterococcus faecium-derived leucic acid from the gut. The finding pushes the classic chain of 'fiber intake → microbial metabolism → host benefit' down to the causal level of a specific strain, a specific metabolite and a specific effect, providing a new molecular interface for microbiome-targeted precision nutrition and suggesting that responses to the same fiber may vary across individual gut microbiome backgrounds.

中NutraIngredients 报道，Elixinol Wellness 宣布计划收购澳大利亚个性化营养公司 Vitable，正值全球资本市场对个性化健康兴趣升温之际。个性化营养通过问卷、检测与算法为用户定制补充剂组合，正在从初创赛道进入主流营养企业并购清单。该交易显示“检测-定制-订阅”模式商业模型获验证，也预示精准营养的行业整合与渠道规模化竞争将加剧。

ENNutraIngredients reports that Elixinol Wellness announced plans to acquire Australian personalized nutrition firm Vitable, amid growing global capital-market interest in personalized health. Personalized nutrition — which customizes supplement regimens via questionnaires, testing and algorithms — is moving from a startup niche onto mainstream nutraceutical M&A lists. The deal validates the 'assess-customize-subscribe' business model and signals intensifying industry consolidation and scale competition in precision nutrition channels.

中Kaiviti Consulting 总裁 Mark Miller 博士在 NutraIngredients 发表专栏，指出围绕甜菜根与硝酸盐降血压的网络传播充斥夸大、断章取义与错误信息：剂量、急性与慢性效应、不同人群反应差异常被混为一谈。文章呼吁行业以机制与剂量学证据为基础做负责任的科学传播，为精准营养时代“成分-效应-人群”三层证据链的公众沟通提供了警示样本。

ENIn a NutraIngredients opinion column, Dr. Mark Miller, president of Kaiviti Consulting, argues that online communication around beets and nitrate-mediated blood pressure reduction is rife with exaggeration, out-of-context claims and disinformation — doses, acute versus chronic effects and inter-individual variability are routinely conflated. The piece calls for responsible science communication grounded in mechanism and dosing evidence, serving as a cautionary example of how the ingredient-effect-population evidence chain should be conveyed in the precision nutrition era.

中MDPI Nutrients 刊发综述，系统梳理甲基供体、多酚、短链脂肪酸、Ω-3 等膳食因子如何通过 DNA 甲基转移酶与组蛋白去乙酰化酶调节表观基因组，并提出“营养基因组学-菌群-表观基因组轴”概念框架：菌群衍生代谢物影响宿主染色质结构与基因表达。作者同时强调，当前人体证据对“表观基因组可被饮食改变”的支持强于对“临床获益”的支持，该框架应视为产生假设的研究工具而非成熟临床路径。

ENA review in MDPI Nutrients systematically maps how dietary factors — methyl donors, polyphenols, short-chain fatty acids and omega-3s — modulate the epigenome via DNA methyltransferases and histone deacetylases, and proposes the 'Nutrigenomics–Microbiome–Epigenome Axis' framework in which microbiota-derived metabolites shape host chromatin architecture and gene expression. The authors stress that human evidence supports biological responsiveness of the epigenome to diet more strongly than clinical utility, positioning the framework as hypothesis-generating rather than a validated clinical pathway.

中NutraIngredients 深度文章指出，植物雌激素的绝经后健康获益远不止“模拟激素”一条路径：其代谢产物（如雌马酚）依赖个体肠道菌群组成，可经由非受体介导途径影响骨代谢、心血管与认知等多个系统。文章提示，菌群代谢能力差异或是既往干预研究结果不一的关键解释，未来植物雌激素补充策略应纳入菌群分型，为围绝经期女性精准补剂设计提供新依据。

ENA NutraIngredients deep-dive argues that the post-menopausal benefits of phytoestrogens extend well beyond 'hormone mimicry': their metabolites (such as equol) depend on individual gut microbiome composition and can act through non-receptor-mediated pathways influencing bone, cardiovascular and cognitive health. Inter-individual differences in microbial metabolism may explain inconsistent intervention results, and future phytoestrogen supplementation strategies should incorporate microbiome profiling — a new basis for designing precision supplements for perimenopausal and postmenopausal women.

中NutraIngredients 报道，橄榄油加工产生的大量果渣、叶片与废水中富含羟基酪醇、橄榄苦苷等多酚类抗氧化物，正被重新定位为天然抗氧化剂原料来源。提取技术进步使副产物中的活性成分回收率与纯度显著提升，既回应了市场对清洁标签天然抗氧化方案的需求，也为榨油产业链提供了循环经济增值路径，“从废料到成分”成为补剂原料创新的重要方向。

ENNutraIngredients reports that the pomace, leaves and wastewater generated by olive oil processing are rich in hydroxytyrosol, oleuropein and other polyphenolic antioxidants, and are being repositioned as natural antioxidant ingredient sources. Advances in extraction have significantly improved recovery and purity of active compounds from by-products, responding to clean-label demand for natural antioxidant solutions while adding circular-economy value to the olive oil chain — 'from waste to ingredient' is emerging as a key direction in supplement raw-material innovation.

中新西兰政府提出新规，拟允许出口的健康补剂产品在符合进口目的地法规的前提下使用治疗性声称，业界普遍表达支持。支持者认为此举将提升新西兰补剂在全球市场的竞争力与合规确定性；评论同时强调，声称必须以科学证据与目标市场批准为前提。该动议与全球补剂监管分化趋势并行，为出口型营养企业提供了观察“证据分级+市场适配”监管思路的新样本。

ENThe New Zealand government has proposed new rules allowing exported health supplements to carry therapeutic claims, provided they comply with the regulations of destination markets — a move broadly welcomed by industry. Supporters say it would boost the competitiveness and regulatory certainty of New Zealand supplements globally, while commentators stress that claims must rest on scientific evidence and destination-market approval. The proposal, aligned with the global trend of divergent supplement regulation, offers export-oriented nutraceutical firms a new case study in 'evidence grading plus market-fit' regulatory thinking.

中NutraIngredients 分析指出，随着女性健康成为补剂行业增长最快的品类之一，社交媒体上围绕围绝经期、激素与补剂的科学传播质量参差不齐，夸大与误读并存。文章呼吁品牌在品类红利期把证据透明度与专业审核机制置于营销增长之前，建立可追溯的声称审核流程；科学传播能力正成为女性健康赛道区别于流量竞争的核心壁垒。

ENA NutraIngredients analysis notes that as women's health becomes one of the fastest-growing supplement categories, the quality of social-media science communication around perimenopause, hormones and supplements is highly uneven, mixing exaggeration with misreading. The piece urges brands, during this category boom, to put evidence transparency and professional review ahead of marketing growth by establishing traceable claim-approval processes. Science communication capability is becoming the core differentiator in the women's health category, beyond traffic-driven competition.

中发表于《欧洲心脏杂志》的 SELECT 试验事后分析显示：在 17,604 名超重/肥胖受试者中，司美格鲁肽组严重心血管事件风险降低约 20%，但体重、腰围、血压、血脂、炎症与肾功能等已知风险因素的改善合计仅能解释其中约一半获益。爱丁堡大学 Helen Colhoun 团队认为，剩余效应可能来自未被充分捕捉的抗炎作用或对心肌、血管内皮的直接作用，司美格鲁肽应被视为心血管疾病减险药物而非单纯减重药。

ENA post-hoc analysis of the SELECT trial published in the European Heart Journal shows that among 17,604 participants with overweight or obesity, semaglutide reduced serious cardiovascular events by about 20%, yet improvements in known risk factors — weight, waist circumference, blood pressure, lipids, inflammation and kidney function — together explained no more than half of the benefit. Helen Colhoun's team at the University of Edinburgh suggests the remaining effect may arise from anti-inflammatory actions or direct effects on myocardium and vascular endothelium, concluding semaglutide should be considered a cardiovascular risk-reduction drug, not merely a weight-loss drug.

中北京医院（国家老年医学中心）联合中国器官移植发展基金会主办的 2026 医学前沿创新大会在北京召开，集中展示我国老年医学与医学前沿创新成果，发布 15 项行业标准、诊疗指南及专家共识，设心血管、内分泌代谢、衰老标志物及干预、健康体重管理等 11 个分会场。会议提出老年医学正从“单病诊治”走向“整体健康管理”、从“被动治疗”走向“主动健康”、从“经验医学”走向“数智驱动”的范式转型。

ENThe 2026 Medical Frontier Innovation Congress, hosted by Beijing Hospital (National Center of Gerontology) with the China Organ Transplantation Development Foundation, convened in Beijing, showcasing national innovation in geriatric medicine and releasing 15 industry standards, clinical guidelines and expert consensus across 11 tracks including cardiovascular care, endocrine-metabolic disease, aging biomarkers and interventions, and healthy weight management. The congress framed a paradigm shift for geriatric medicine: from single-disease treatment to holistic health management, from passive care to proactive health, and from empirical medicine to data-driven practice.

中ScienceDaily 报道，研究人员通过脑成像获得证据提示，长新冠可能损伤大脑中释放多巴胺的神经元，从而解释患者持续的疲劳、动力低下、动作迟缓与记忆困难等症状。这一发现将长新冠从功能性主诉推向可测量的神经机制层面，为开发针对多巴胺通路的诊断标志物与治疗策略提供了方向，也为慢性疲劳相关健康管理的评估体系提供了新参照。

ENScienceDaily reports that researchers have found imaging evidence suggesting long COVID may damage dopamine-releasing neurons in the brain, potentially explaining persistent fatigue, low motivation, slowed movement and memory difficulties in patients. The finding moves long COVID from functional complaint toward measurable neural mechanism, pointing to diagnostic biomarkers and treatment strategies targeting dopaminergic pathways, and offering a new reference for assessment frameworks in health management of chronic fatigue conditions.

中国家卫健委在其官网公开对全国人大代表建议的答复，系统披露基层慢性病健康管理新政进展：推广家庭医生签约服务健康行为积分并允许兑换健康服务；指导有需求患者配备智能体重秤、可穿戴智能检测设备，探索将智能终端监测数据上传至居民电子健康档案；同步推进全民健康信息平台建设、检查检验结果跨省互认与电子健康档案向本人开放，为“个人健康画像+风险预警”式闭环健康管理铺路。

ENChina's National Health Commission publicly released its response to a deputy's recommendation, detailing progress in grassroots chronic-disease health management: promoting health-behavior points within family-doctor contracts redeemable for services; guiding patients who need them to use smart scales and wearable devices, with device data explored for upload into residents' electronic health records; and advancing the national health information platform, cross-province mutual recognition of test results, and personal access to EHRs — paving the way for closed-loop health management built on personal health profiles and risk alerts.