全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中挪威五家医院开展的随机双盲安慰剂对照三期试验纳入 450 例中重度肠易激综合征患者，按 2:1 随机接受一次供体或自身粪菌灌肠。90 天时症状严重度评分改善达 75 分及以上者供体组 40%、安慰剂组 38%，绝对差异仅 1.9 个百分点，未达统计学显著。作为迄今规模最大的 FMT 治疗 IBS 严格对照试验，结果提示其疗效并不确凿，供体筛选与制剂优化仍是未来关键。

ENA randomized, double-blind, placebo-controlled phase 3 trial across five Norwegian hospitals enrolled 450 patients with moderate-to-severe IBS, randomized 2:1 to a single donor or self faecal enema. At 90 days, 40% of the donor-FMT group versus 38% of the placebo group achieved a 75-point or greater drop in symptom severity — an absolute difference of only 1.9 percentage points. As the largest rigorously controlled FMT trial in IBS, the results suggest its efficacy remains unproven, keeping donor selection and formulation optimization as key challenges.

中晋城市人民医院消化内科首次开展两例精准肠道菌群移植均获显著疗效：一例长期慢性腹泻患者移植后大便成形、症状明显缓解；一例合并血糖异常的 12 岁自闭症女孩移植三个月后血糖显著下降，且性格转为活泼开朗。团队指出菌群重建可能经肠-脑轴同时影响代谢与情绪行为，填补了晋城地区微生态治疗空白，后续将推进规范化应用。

ENThe gastroenterology team at Jincheng People's Hospital reported two successful precision fecal microbiota transplantations: a chronic diarrhea patient achieved formed stools and marked symptom relief, while a 12-year-old autistic girl with abnormal glucose saw her blood sugar fall significantly and her personality become markedly more outgoing three months after the procedure. The team notes microbial reconstruction may simultaneously influence metabolism and emotional behavior via the gut-brain axis.

中发表于 Science 的研究揭示高脂饮食促进结直肠癌转移的关键通路：膳食脂质负荷上调神经酰胺合成，后者激活 YAP 驱动的再生程序，使肿瘤细胞获得更强的侵袭与定植能力。该发现把饮食脂肪、鞘脂代谢与肿瘤干性联系起来，为功能医学视角下以膳食结构和代谢干预降低肠癌转移风险提供了新靶点。

ENA study in Science uncovers a key pathway by which a high-fat diet promotes colorectal cancer metastasis: dietary lipid load upregulates ceramide synthesis, which activates a YAP-driven regenerative program endowing tumor cells with enhanced invasive and colonizing capacity. Linking dietary fat, sphingolipid metabolism and tumor plasticity, the finding offers fresh targets for reducing metastatic risk through dietary patterning and metabolic intervention.

中先天性巨结肠相关肠炎（HAEC）是患儿致命并发症。发表于 Gastroenterology 的小鼠研究显示，特定膳食干预可同时保护肠道上皮线粒体功能并抑制致炎肠杆菌扩张，从而显著延长模型小鼠生存期。研究证明在不改变基因背景的前提下，精准的营养处方能够重塑微生态、降低肠炎风险，为高危患儿的膳食管理提供循证方向。

ENHirschsprung-associated enterocolitis (HAEC) is a life-threatening complication for affected children. A mouse study in Gastroenterology shows that targeted dietary modulation simultaneously protects epithelial mitochondrial function and curbs inflammatory Enterobacteriaceae overgrowth, significantly prolonging survival — evidence that precision nutrition prescriptions can reshape the microbiota and reduce enterocolitis risk without altering genotype.

中9 月 23 日 Nature 背靠背发表两项研究：果蝇幼年期限制蛋白，即使成年后恢复正常饮食，寿命仍延长。研究者鉴定脂质转运蛋白 Lsp2 为「营养史的分子载体」，它把早期饮食信息带入成虫期，并通过放大 mTORC1 输出调控衰老。结合英国生物样本库 6.4 万人早期糖配给队列证据，提示生命早期营养可能是长寿医学被低估的干预窗口，但能否外推到人类仍待验证。

ENTwo Nature papers published on Sep 23 show that restricting protein in young fruit flies extends lifespan even after returning to a normal adult diet. The lipid-transport protein Lsp2 acts as a molecular carrier of nutritional history, carrying early-life dietary information into adulthood and modulating longevity by amplifying mTORC1 output. Together with UK Biobank evidence from sugar-rationing cohorts, the work hints that early-life nutrition may be an underestimated longevity window in humans.

中ScienceDaily 报道的新研究发现，增龄相关的肌力下降并非仅源于肌肉萎缩，还存在此前被忽视的神经与肌肉之间通讯失灵：连接信号随衰老衰减，导致运动单位募集不足。研究团队在动物模型中靶向关键蛋白干预后肌力显著改善，提示恢复神经-肌肉突触功能可能成为肌少症与老年虚弱的新治疗路径。

ENA newly identified breakdown in communication between nerves and muscles — beyond muscle wasting itself — may explain age-related strength loss, as connection signals decay and impair motor-unit recruitment. Targeting a key protein restored muscle strength in an animal model, suggesting re-establishing neuromuscular synaptic function as a promising therapeutic route for sarcopenia and frailty.

中新研究显示，替尔泊肽（Mounjaro/Zepbound）在肥胖小鼠中激活了耗能的棕色脂肪组织，提示其强大减重与降糖效果可能部分来自食欲抑制之外的产热代谢通路。若在人体得到证实，这一机制将解释 GLP-1/GIP 双靶点药物的部分代谢获益来源，并为联合能量消耗通路的下一代肥胖与糖尿病疗法提供思路。

ENTirzepatide (Mounjaro/Zepbound) activated calorie-burning brown fat in obese mice, hinting that its powerful weight-loss and glucose benefits may partly stem from thermogenic pathways beyond appetite suppression. If confirmed in humans, the finding could explain part of the metabolic benefit of dual GLP-1/GIP agonism and inspire next-generation obesity and diabetes therapies that couple energy expenditure.

中日本近畿大学与金泽大学团队利用无菌果蝇定植基因工程大肠杆菌的体系，首次把「菌群代谢物」与「膳食多胺」的贡献分开：无论经膳食补充还是由菌株合成，腐胺与亚精胺均使果蝇平均寿命从约 18 天延长至 21 天左右。该因果性证据强化了亚精胺等菌群代谢物作为延寿营养靶点的地位，也提示调控产多胺菌株或成精准营养新策略。

ENUsing gnotobiotic flies colonized with engineered E. coli, Japanese researchers separated the contribution of microbiota-derived metabolites from dietary polyamines: putrescine and spermidine, whether supplied in food or produced by the bacteria, extended mean fly lifespan from about 18 to 21 days. This causal evidence strengthens spermidine-type microbial metabolites as longevity nutrient targets and points to tuning polyamine-producing strains as a precision nutrition strategy.

中发表于 Nature Communications 的跨国研究分析了五个国家人群的肠道菌群组成与基因组变异，发现健康膳食与菌群特征之间的关联存在显著地理与膳食结构差异：同一「健康饮食」在不同人群中被不同的物种与功能基因承载。结果提示菌群导向的膳食建议必须结合本地膳食文化与人群基线，为分层化、本地化的精准营养干预提供证据。

ENA five-country analysis in Nature Communications maps gut microbiome composition and genomic variation against dietary patterns, showing that associations between healthy eating and microbial features differ markedly by geography and diet: the same healthy diet is carried by different species and functional genes across populations. Microbiome-directed dietary guidance must therefore be localized, supporting stratified precision nutrition interventions.

中发表于 Genome Medicine 的研究用机器学习整合肠道菌群与临床指标，预测延长禁食后能否持续减重：基线菌群特征与临床变量共同决定个体应答差异，部分人群减重效果显著而另一些人迅速反弹。研究为「先测菌群再定禁食处方」的精准体重管理提供框架，也解释了同一禁食方案在不同个体间疗效悬殊的原因。

ENMachine learning models integrating gut microbiome and clinical features can predict who sustains weight loss after prolonged fasting. Baseline microbial signatures and clinical variables jointly explain individual response variability, with some individuals responding strongly while others rapidly regain weight. The study frames a test-first approach to fasting prescriptions for precision weight management.

中一项中国大型研究显示，孕母维生素 A 及 EPA、DHA 等 Ω-3 脂肪酸水平不足与 37 周前早产风险升高相关，并阐明这些营养素在胎盘发育、炎症调控与胎儿生长中的作用。研究者建议孕妇关注维 A 与 Ω-3 的适宜摄入，同时警惕维 A 与 Ω-6 过量带来的反向风险，体现孕期营养「补足与限量并重」的精准思路。

ENA large Chinese study links insufficient maternal vitamin A and omega-3 (EPA/DHA) status to elevated risk of preterm birth before 37 weeks, clarifying these nutrients' roles in placental development, inflammation control and fetal growth. Adequate intake matters — alongside caution against excess vitamin A and omega-6 — exemplifying the dual imperative of repletion and limits in pregnancy nutrition.

中中国农业大学李媛、陈莎男团队在 Advanced Materials 发表研究，通过调控纳米纤维素微凝胶的几何形状与力学特性，使益生菌在不同肠道区域实现定点释放：形状决定其在胃肠道的滞留、耐受与解体位置。该材料学策略绕开了传统包埋「一刀切」的困境，为菌-靶点匹配的下一代精准益生菌制剂提供工程化路径。

ENResearchers at China Agricultural University report in Advanced Materials that tuning the geometry and mechanics of nanocellulose microgels directs probiotic release to specific intestinal regions, with shape governing retention, tolerance and disintegration sites along the gut. The materials strategy enables next-generation probiotics matched to target segments, moving beyond one-size-fits-all encapsulation.

中发表于 Childhood Obesity 的研究追踪使用 GLP-1 类药物（Victoza、Saxenda、Trulicity、Ozempic 等）减重或治疗糖尿病的儿童，发现近 1/6（16.8%）在开始用药一年内出现确诊的营养缺乏，其中维生素 D 缺乏约占 12%。食欲受抑叠加饮食结构改变是重要机制，提示儿科 GLP-1 治疗须同步开展微量营养素监测与补充方案，不可只盯体重曲线。

ENA study in Childhood Obesity found that nearly one in six children (16.8%) prescribed GLP-1 medications such as Victoza, Saxenda, Trulicity or Ozempic developed a diagnosed nutritional deficiency within a year of starting treatment, with vitamin D deficiency affecting about 12%. Suppressed appetite and dietary shifts are key mechanisms, underscoring the need for micronutrient monitoring alongside pediatric GLP-1 therapy.

中发表于 Nutrition Research 的人群研究显示，来自富脂鱼类与鱼油的 EPA、DHA 摄入更高与癌症患者长期生存改善相关，并可能通过抗炎、影响细胞信号与代谢等机制参与肿瘤预防。作者强调观察性证据不支持「鱼油抗癌」的简单结论，但提示肿瘤康复人群维持充足 Ω-3 状态是值得纳入营养管理策略的环节。

ENA population-based study in Nutrition Research reports that higher intake of EPA and DHA from fatty fish and fish oil is associated with longer survival among cancer patients, with anti-inflammatory and metabolic mechanisms possibly contributing to prevention as well. The observational evidence does not support simplistic anti-cancer claims, but maintaining adequate omega-3 status is worth including in oncology nutrition strategies.

中路博润联合 IQVIA 完成的亚太消费者研究显示，中国女性对生命周期定制补剂需求强烈：87% 按生命阶段选购产品，93% 认为需要面向孕妇的铁与营养方案，亚太多数受访者认为现有产品不完全起效。中国「主动健康指数」34.3% 居三国之首，孕产人群愿为降低不确定性支付最高 50% 溢价，为母婴与更年期细分补剂市场划出增量方向。

ENA Lubrizol-IQVIA consumer study across China, South Korea and Indonesia finds Chinese women strongly prefer life-stage-specific supplements: 87% choose products by life stage, 93% see a need for pregnancy-focused iron and nutrition solutions, and many report current products only partly work. With China's proactive wellness index highest at 34.3% and mothers willing to pay up to 50% premiums, the data highlight clear growth lanes in maternal and menopause supplement segments.

中挪威制剂企业 Concordix 在 SupplySide Global 2026 展出新一代咀嚼片概念：将后生元与生物素、维生素 D3 组合，定位于皮肤、头发与免疫健康的交集场景。咀嚼与无水服用形式持续从传统片剂胶囊分流份额，后生元则因规避活菌稳定性难题成为配方热点，折射出补剂行业向「便捷剂型×温和成分×多靶点声称」的融合趋势。

ENNorwegian dose-form specialist Concordix unveiled chewable concepts pairing postbiotics with biotin and vitamin D3 for skin, hair and immune health at SupplySide Global 2026. Chewable, water-free formats keep taking share from tablets and capsules, while postbiotics sidestep live-probiotic stability issues — reflecting the industry drift toward convenient formats, gentle actives and multi-target claims.

中国家卫健委新闻发言人胡强强在 9 月 23 日发布会上回应近期减肥训练营伤亡事件：以「急速暴瘦」「不瘦退款」招揽学员的过度节食、超负荷训练可致脱水、脱发、电解质紊乱与肌肉流失，甚至增加心血管风险。目前超过 95% 的三级公立综合医院设置健康体重管理门诊，体重困扰严重者应先到医疗机构接受评估与指导，减重须以合理膳食、适量运动与生活方式为基础。

ENResponding to recent boot-camp casualties, China's National Health Commission warned that crash diets and overtraining marketed with promises of rapid weight loss can cause dehydration, electrolyte imbalance, muscle loss and cardiovascular risks. Over 95% of tertiary public hospitals now operate weight-management clinics, and people with serious weight problems should seek medical assessment before any program.

中覆盖 13 个省份 25736 名社区成年居民的普通人群肝脏健康项目 9 月 23 日发表于《柳叶刀·胃肠病学和肝脏病学》，首次系统回答我国社区人群肝纤维化与脂肪性肝病患病情况：肝纤维化风险随体重、血糖、血压、饮酒等代谢危险因素累积而显著升高。研究为把肝脏健康管理纳入慢病全程管理与生活方式干预提供流行病学依据。

ENA liver health project covering 25,736 community adults across 13 Chinese provinces, published in The Lancet Gastroenterology & Hepatology, provides the first systematic picture of liver fibrosis and fatty liver disease in the general population: fibrosis risk rises steeply with accumulating metabolic risk factors such as weight, glucose, blood pressure and alcohol. The findings ground liver health in chronic-disease and lifestyle management programs.

中国务院食安办联合中央文明办、农业农村部、市场监管总局等 27 个部门和单位于 9 月 22 日在京启动 2026 年全国食品安全宣传周，主题为「尚德守法 共享食安——深化全链条监管」。宣传周期间将举办 40 余场部委主题日活动，涵盖法规标准宣贯、典型案例发布与食品安全营养科普，并通过「你点我检」等公众参与形式推进社会共治。

ENChina's State Council food safety office launched the 2026 National Food Safety Awareness Week in Beijing on Sep 22 with 27 departments under the theme of deepening whole-chain regulation. More than 40 ministerial theme-day events will cover standards training, case releases and nutrition education, with public participation mechanisms such as the 'you order, we test' program.

中全国儿童青少年「五健」促进行动工作交流会暨培训班近日召开，围绕视力、体重、心理、骨骼、口腔五大健康促进行动部署落地路径，推动各地整合学校、医疗机构与家庭场景开展筛查、干预与健康教育。该行动与「十五五」健康规划中儿童青少年健康促进行动相衔接，是肥胖防控与近视、脊柱问题协同治理的重要抓手。

ENA national exchange and training session for the 'Five Healths' initiative for children and adolescents laid out implementation pathways across vision, weight, mental health, bone and oral health, mobilizing schools, medical institutions and families for screening, intervention and education. The program aligns with the 15th Five-Year health plan's child and adolescent health promotion actions.