全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中《Gut》发表一项跨国宏基因组研究，发现肝硬化住院患者的肠道菌群在结构与功能上呈现独特特征。研究将菌群数据与机器学习相结合，显著提升了肝硬化病情与住院风险的预测效能，提示菌群标志物有望并入临床预后评估体系，为功能医学视角下的肝病管理提供新的分层工具。

ENA multinational metagenomic study in Gut found that hospitalized patients with cirrhosis carry distinct gut microbiome structural and functional profiles. Combining microbiome features with machine learning markedly improved prediction of disease course and hospitalization risk, suggesting microbiome markers could join clinical prognostic models for liver disease management.

中《Allergy》发表 PRISM 研究成果：研究者在多腔室前瞻框架下分析重度哮喘患者的粪便与气道菌群及囊泡特征，发现其与抗 IL-4R 靶向药度普利尤单抗的治疗应答显著相关。这提示未来启动昂贵生物制剂治疗前，或可先通过无创粪便样本为患者绘制菌群地图，精准筛选最可能获益的个体，迈向重度哮喘的个体化精准干预。

ENThe PRISM study in Allergy analyzed stool and airway microbiome plus vesicle signatures in severe asthma, finding them significantly associated with treatment response to the anti-IL-4R biologic dupilumab. Non-invasive stool-based microbiome mapping could help clinicians pre-select patients most likely to benefit before starting costly biologics.

中团队在《NPJ Biofilms and Microbiomes》发布 OAPGC 口腔与气道原核生物基因组目录，整合超9.9万个高质量基因组。分析全球1.6万余份粪便样本发现约12.3%的口腔/气道物种可迁移入肠，在肝硬化、结直肠癌等疾病状态下多样性与累积丰度显著攀升，将其纳入模型可提升结直肠癌交叉诊断性能，为呼吸与消化系统疾病的精准诊疗提供共享参考资源。

ENPublished in NPJ Biofilms and Microbiomes, the OAPGC catalog integrates over 99,000 high-quality oral and airway prokaryotic genomes. Analysis of 16,000+ global fecal samples showed about 12.3% of oral/airway species can migrate into the gut, rising markedly in cirrhosis and colorectal cancer and improving cross-cohort CRC diagnostic performance when included in models.

中《Gut Microbes》刊登奥斯陆大学研究，基于1034名老年人粪便宏基因组构建了含约1700种原核生物、1.95万个病毒与7.4万个CRISPR-Cas免疫库的大规模图谱。细菌的CRISPR间隔序列高度个性化，显著倾向靶向同一样本中共存的移动遗传元件，免疫记忆由局部微环境暴露驱动，并与宿主生活方式相关，甚至可追溯出与高频乳制品摄入相关的双歧杆菌保守免疫记忆。

ENAn Oslo University study in Gut Microbes built a large-scale catalog from 1,034 older adults comprising ~1,700 prokaryotes, 19,500 viruses and 74,200 CRISPR-Cas immune records. CRISPR spacers were highly individualized and preferentially targeted co-resident mobile elements, driven by local microenvironment exposure and linked to host lifestyle, including conserved immune memory in Bifidobacterium tied to frequent dairy intake.

中东京大学团队在《npj Aging》发表62名健康老年人参与的随机双盲安慰剂对照试验：每日1250mg NMN持续24周显著提升血液NAD+及多种相关代谢物，但听力、握力、步速、30秒坐立、6分钟步行等衰老相关终点均无显著改善。高剂量下安全性总体良好，但一例基线肝酶异常者转氨酶进一步升高，提示NMN抗衰证据仍不足、肝功能异常人群需谨慎。

ENA randomized, double-blind, placebo-controlled trial in npj Aging enrolled 62 healthy older adults: 1,250 mg/day NMN for 24 weeks significantly raised blood NAD+ and related metabolites, but showed no significant improvement in hearing, grip strength, gait speed, 30-second chair stand or six-minute walk. Safety was generally good, though one participant with baseline liver-enzyme abnormalities worsened, underscoring that anti-aging evidence remains insufficient.

中长寿营养公司 L-Nutra 宣布其5日模拟禁食饮食（FMD）产品 Prolon 问世十周年：累计持有136项长寿与疾病缓解相关专利、完成40余项临床试验，获1.2万余名执业医师处方推荐。据披露，近期两项人体试验显示连续三个周期可诱导细胞自噬并使生物学年龄平均逆转2.5岁，公司已完成由 Mubadala 领投的8350万美元D轮融资，目标未来十年惠及一亿人。

ENLongevity nutrition company L-Nutra marked ten years of Prolon, its 5-day fasting-mimicking diet: 136 patents in longevity and disease remission, 40+ completed clinical trials and recommendations from 12,000+ practitioners. Recent human trials reportedly showed autophagy induction and an average 2.5-year reversal of biological age after three cycles; the company closed an $83.5M Series D led by Mubadala.

中精准健康公司 BioAro 继迪拜首发后，将 LONgevity+ 长寿生物活性物组合推向美英市场。其配方结合科学文献分析、生物通路研究与AI辅助研发，围绕细胞能量、代谢调节、氧化应激与炎症等衰老机制进行组合式设计，并通过 BioAro Intelligence 平台以「健康目标—方案」结构连接产品、成分与科学依据，体现AI驱动个性化长寿补剂的新路径。

ENFollowing its Dubai debut, BioAro brought its LONgevity+ longevity bioactives to the U.S. and U.K. Formulations combine biotech literature analysis, biological pathway research and AI-assisted development around cellular energy, metabolic regulation, oxidative stress and inflammation, while the BioAro Intelligence platform organizes products and evidence into goal-based protocols — an AI-driven approach to personalized longevity supplements.

中长寿科技产学研生态共建专题报告会9月22日在中南大学湘雅医学院举行，高校、医疗与康养产业近130名代表参会。长寿科技品牌生命记发布「预见时光」衰老时钟评估与「溯光系列五维营养支持体系」，确立指标具备循证依据、依托中南大学科研底座、适配体检与健康管理机构场景三大标准，形成「评估—干预」服务闭环，推动生物学年龄评估从实验室走向普惠健康服务。

ENA longevity-tech industry-academia symposium was held at Central South University Xiangya School of Medicine with nearly 130 participants. The brand Shengmingji launched the foreseeTime aging-clock assessment and a five-dimension nutrition support system, setting standards for evidence-based indicators, university-backed research and fitness for physical-exam and health-management settings, forming an assessment-intervention loop that brings biological-age evaluation into mainstream services.

中由农业农村部食物与营养发展研究所、中国中医科学院、北京中医药大学、中国农业科学院等权威机构联合圣泽松生物集团共同参与的《精准营养产品研发指南》团体标准近日启动编制，将明确从原料筛选、配方设计、功效研究、安全性评估到产品上市评价的全链条研发规范，建立科学、可落地的评价体系，补齐国内精准营养产品标准短板，助推大健康产业提质升级。

ENA group standard, the Precision Nutrition Product Development Guidelines, has begun drafting with participation from the Institute of Food and Nutrition Development (MARA), China Academy of Chinese Medical Sciences, Beijing University of Chinese Medicine and others. It will define end-to-end R&D norms covering ingredient screening, formulation, efficacy research, safety assessment and market evaluation, filling a standards gap in China's precision nutrition industry.

中浙江大学阎芙洁副研究员等撰文指出，B族维生素既是中枢神经系统合成5-羟色胺、多巴胺、GABA等神经递质的必需辅因子，也是肠道菌群代谢的枢纽分子；地中海饮食等富含全谷物、膳食纤维与益生元的模式可促进产B族维生素益生菌增殖。文章提出未来可结合MTHFR基因多态性检测与微生物组测序，为患者定制活性形式B族维生素与针对性益生菌组合的个体化营养干预。

ENA science feature by Zhejiang University researchers on the CIFST platform explains that B vitamins serve as essential cofactors for neurotransmitter synthesis while also acting as hub molecules in gut microbial metabolism; fiber- and prebiotic-rich diets boost B-vitamin-producing probiotics. Future individualized interventions may combine MTHFR polymorphism testing with microbiome sequencing to tailor active B-vitamin and probiotic combinations.

中据山西经济日报报道，2026年全球个性化营养补剂市场规模预计达124亿美元、年复合增长14.7%。康宝莱以最高1.5亿美元收购Bioniq，Rem3dy Health完成1400万英镑融资；国内定制营养品牌「营养日记」基于《Cell》衰老标志物框架研发7D评估模型，以月费约400元的「测—补—验—调」方案切入一、二线城市，而传统龙头汤臣倍健两年营收缩水超30亿元，行业竞争逻辑正被定制化改写。

ENPer Shanxi Economic Daily, the global personalized nutrition supplement market is projected at $12.4 billion in 2026, growing 14.7% annually. Herbalife acquired Bioniq for up to $150M and Rem3dy Health raised £14M; in China, the custom-nutrition brand Yingyang Riji applies a 7D assessment model built on Cell's hallmarks of aging with a roughly 400-yuan monthly test-supplement-verify-adjust plan, while incumbent By-Health has lost over 3 billion yuan in revenue across two years.

中《Nutrients》发表的叙事综述梳理了地中海饮食与菌群功能、免疫调节、肠屏障完整性及阿尔茨海默病、帕金森病相关脑改变的关联证据，认为其经菌群重塑发挥神经保护作用具有生物学合理性，但尚不能确立因果方向。作者建议结合AI可穿戴饮食监测与菌群标志物开展长期干预研究，推动认知衰老与神经退行性疾病预防的精准营养策略。

ENA narrative review in Nutrients synthesized evidence linking Mediterranean-diet adherence to microbiome function, immune regulation, intestinal barrier integrity and neurodegeneration-related brain changes in Alzheimer's and Parkinson's disease. The gut-mediated neuroprotection is biologically plausible but causality is unproven; the authors propose AI-enabled wearable dietary monitoring plus microbiome markers for long-term trials to advance precision nutrition for cognitive aging.

中NutraIngredients 分析指出，源自鲑鱼生殖组织的多聚脱氧核糖核苷酸（PDRN）在韩国医美注射领域应用多年，正快速向口服美容补剂扩展，主打皮肤再生、屏障修复与抗光老化方向。行业观察认为 PDRN 有望接棒胶原蛋白与烟酰胺成为「beauty from within」新晋热点，但其口服后的剂量换算、吸收路径与临床证据仍待更多研究完善。

ENNutraIngredients reports that polydeoxyribonucleotide (PDRN), long used in Korean aesthetic medicine injections, is rapidly expanding into oral beauty-from-within supplements targeting skin regeneration, barrier repair and anti-photoaging. Analysts see PDRN as a potential next trending ingredient after collagen and niacinamide, though oral dosing, absorption pathways and clinical evidence still need strengthening.

中《Phytomedicine》刊载川北医学院附属医院林菁艳团队研究：槲皮素干预可重塑糖尿病神经痛模型的肠道菌群结构，并伴随脊髓甜菜碱相关代谢改变，经「肠—脊髓」代谢轴减轻神经病理性疼痛。研究为植物来源活性成分经菌群途径干预糖尿病并发症提供了新机制证据，也为槲皮素类补剂的功能定位与后续临床转化提供了参考。

ENA Phytomedicine study by Lin Jingyan's team at North Sichuan Medical College shows quercetin reshapes gut microbiota in painful diabetic neuropathy models alongside spinal betaine-related metabolic changes, easing neuropathic pain through a gut-spinal metabolic axis. The work offers mechanistic support for plant-derived actives targeting diabetic complications via the microbiome and informs positioning of quercetin supplements.

中希吉亚生物宣布旗下 Enerlive Ca-AKG、SirtuAct NMN 与 DeazaKing 脱氮黄素三款原料同获 FDL 数食主张「2026年度适老化营养产品力创新认证」。三款原料分别对应健康衰老与代谢、成熟NAD+前体的工艺竞争与前沿抗衰分子布局；公司依托 Zymevolver 合成生物平台、1500平米研发中试平台与8000平米GMP车间，强调从分子发现到稳定供应的全链路原料能力。

ENHygieia Biotech announced that three ingredients — Enerlive Ca-AKG, SirtuAct NMN and DeazaKing deazaflavin — won FDL's 2026 senior-nutrition product innovation certification. Spanning healthy-aging metabolism, mature NAD+-precursor manufacturing and next-generation anti-aging molecules, the portfolio leverages the Zymevolver synthetic-biology platform with GMP production, highlighting full-chain ingredient capabilities from discovery to stable supply.

中Rising Trends 发布9月补剂搜索趋势报告：虾青素以月搜索30.1万次、同比+307%成为增长最快的长寿成分，谷胱甘肽+50%（脂质体形式+123%）、纳豆激酶+173%、NMN+172%、尿石素A+123%持续升温；小檗碱热度持平且近三月下降18%。报告同时警示 BPC-157、MOTS-c 等实验性研究肽搜索激增但证据不足，应在专业医学监督下谨慎对待。

ENRising Trends' September report shows astaxanthin as the fastest-rising longevity term (301,000 monthly searches, +307% YoY), with glutathione +50% (liposomal +123%), nattokinase +173%, NMN +172% and urolithin A +123%; berberine is flat and down 18% over three months. The report cautions that experimental research peptides like BPC-157 and MOTS-c are surging in searches despite limited evidence and warrant medical supervision.

中超超AI健康生活方式体验馆9月28日在北京昌平未来科学城启幕，设置运动疗法、中医养生、营养免疫、居家康养、健康管理等功能区，公众可体验VR运动、律动健康椅及由清华长庚医院AI健康联合研发中心等联合研发的SupRing智能戒指。体验馆倡导从「被动治疗」到「主动健康」、从「千人一面」到「一人一策」的转变，构建「评估—干预—监测—反馈」闭环，呼应「人工智能+医疗卫生」政策方向。

ENThe Chaochao AI healthy-lifestyle experience center opened in Changping Future Science City on Sept 28, with zones for exercise therapy, TCM wellness, nutritional immunity, home care and health management. Visitors can try VR exercise, vibration chairs and the SupRing smart ring co-developed with Tsinghua Changgung Hospital's AI health center, embodying the shift from passive treatment to proactive, personalized health with an assess-intervene-monitor-feedback loop.

中2026年国家健康体重管理中心建设项目启动，依托中央财政专项资金，优先支持国家慢性病综合防控示范区的县级综合医院建设。项目首次将营养管理软件与生活方式评估设备列入必备清单，要求搭建涵盖人体成分、营养代谢评估及营养、运动、心理、睡眠四维个体化干预的一体化服务体系，推动体重管理从门诊向县域中心、从硬件配置向长期运营闭环升级。

ENChina's 2026 national healthy-weight management center program, backed by central funds, prioritizes county-level general hospitals in chronic-disease demonstration zones. Nutrition management software and lifestyle-assessment devices appear on the required equipment list for the first time, mandating an integrated service system covering body-composition and metabolic assessment plus individualized nutrition, exercise, psychological and sleep interventions — shifting weight management from outpatient clinics to county centers with sustainable operations.

中由浙江中医药大学、北京中医药大学王琦书院、国家中医体质与治未病研究院等共同完成的多中心开放标签单臂试验发表于《中医临床研究》：61名超重及肥胖受试者使用神阙穴温灸联合EMS脉冲的智能腹部按摩仪并配合饮食干预2个月，平均减重10.8kg、腰围缩减13.6cm、BMI下降4.1，全部受试者减重≥5%。研究为消费级中医体重管理设备提供循证支撑，但缺乏安慰剂对照，解读需谨慎。

ENA multicenter, open-label, single-arm trial published in TCM Clinical Research, conducted with Zhejiang Chinese Medical University and Beijing University of Chinese Medicine, enrolled 61 adults with overweight or obesity. Two months of a smart abdominal massager combining Shenque-point moxibustion heating with EMS pulses plus dietary intervention yielded mean weight loss of 10.8 kg, waist reduction of 13.6 cm and BMI drop of 4.1; all participants lost ≥5%. Lacking placebo control, results warrant cautious interpretation.

中武汉市卫健委9月28日答复市政协提案称，我国糖尿病患病率超12%，30%-50%人群仅靠空腹血糖筛查会发生漏诊，餐后2小时血糖是识别糖耐量减低与隐匿糖尿病的核心指标。受检测流程、场地人力与成本约束，暂不宜将全员强制列为体检基础项目，将按「高危人群优先纳入、分层设置套餐、标准化流程、全域科普宣教」分步推进，落实糖尿病防治行动实施方案要求。

ENReplying to a CPPCC proposal on Sept 28, the Wuhan Health Commission noted diabetes prevalence exceeds 12% and 30-50% of people are missed by fasting-glucose-only screening; 2-hour postprandial glucose is key to identifying impaired glucose tolerance and occult diabetes. Citing workflow and cost constraints, it will proceed in stages — high-risk groups first, tiered checkup packages, standardized procedures and public education — per the national diabetes prevention and control action plan.