全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中北京地坛医院儿科肠道微生态门诊分享一例5岁孤独症合并顽固便秘患儿的粪菌移植案例：治疗一个月后恢复自主排便，CARS评分与发育商改善，语言互动和目光对视明显增多。报道援引2025版中国专家共识，强调治疗前须完成肠菌、免疫与肠屏障评估，先评估后干预，疗效存在个体差异。

ENBeijing Ditan Hospital's pediatric gut-microecology clinic reported a 5-year-old boy with autism and severe constipation who, one month after fecal microbiota transplantation, regained autonomous bowel movements, with improved CARS scores, development quotient, verbal interaction and eye contact. Citing China's 2025 expert consensus on FMT for pediatric ASD, the report stresses pre-treatment assessment of microbiota, immunity and gut barrier, noting individual variation in response.

中他汀是降胆固醇、预防心脏病与卒中的基石药物，但部分使用者会出现肌肉疼痛、无力甚至严重肌损伤。研究团队借助先进成像技术，揭示了他汀偶发肌肉不良反应的机制。该发现有助于识别高危人群、优化用药与监测策略，在坚持心血管一级预防的同时，更精细地管理他汀不耐受，减少因副作用随意停药带来的风险。

ENStatins are cornerstone drugs for lowering cholesterol and preventing heart attacks and strokes, yet some users develop muscle pain, weakness or, rarely, serious muscle damage. Using advanced imaging, researchers uncovered the mechanism behind these occasional adverse muscle effects. The finding should help identify high-risk patients and refine dosing and monitoring, so cardiovascular prevention can continue while statin intolerance is managed more precisely.

中一项覆盖超过46万美国人的大型队列研究显示，超加工食品总体摄入与结直肠癌风险升高并无关联，对广为流传的"超加工食品致癌"假设提出挑战。研究者提示，健康风险更可能取决于具体食品类别与营养构成，而非"加工"标签本身。这一结果为膳食风险沟通和食品分类政策提供了更精细的证据基础，也提醒公众避免一刀切的恐慌。

ENA large US cohort study of more than 460,000 adults found no overall association between ultra-processed food intake and colorectal cancer risk, challenging a widely held assumption. The authors suggest that health risk depends more on specific food categories and nutritional composition than on the processing label itself. The results offer a more nuanced evidence base for dietary risk communication and food-classification policy.

中光明网报道北京大学国际医院健康长寿整合医学中心李淼医生的功能医学实践：一名58岁男性因抗氧化、自噬、炎症免疫及甲基化通路的基因变异形成代谢瓶颈，经肠道修复与精准营养干预14个月后，影像学观察到颈动脉斑块缩小，炎性标志物同步显著改善，呈现"基因诊断—精准干预—客观验证"的全周期抗衰管理闭环范例。

ENGuangming Online profiles functional medicine practice by Dr. Li Miao of Peking University International Hospital: a 58-year-old man with genetic variants burdening antioxidant, autophagy, immune and methylation pathways received gut-repair and precision-nutrition interventions. After 14 months his carotid plaque shrank on imaging and inflammatory markers improved markedly, illustrating a full-cycle anti-aging loop of genetic diagnosis, targeted intervention and objective re-testing.

中The Longevity Review解析Seragon组合物SRN-901新论文：该多分子疗法覆盖mTOR、自噬、线粒体自噬、衰老细胞清除与NAD+等通路。18月龄小鼠干预使剩余中位寿命延长33%，死亡风险降低46%，衰弱进展衰减约70%，肿瘤发生率亦下降；同实验中NMN与NR未优于安慰剂。

ENThe Longevity Review analyzes Seragon's new paper on the combination therapy SRN-901, a multi-molecule design covering mTOR inhibition, autophagy, mitophagy, senescent-cell clearance, inflammation and NAD+ pathways. In 18-month-old mice it raised median remaining lifespan from 263.5 to 350.5 days (+33%), cut mortality risk by 46%, attenuated frailty progression by about 70% and lowered tumor incidence, while NMN and NR showed no significant benefit in the same test.

中动脉网独家报道，南京瑞初医药10月21日完成数亿元超额认购A轮融资，由凯辉基金、复健资本、倚锋资本与华泰金斯瑞联合投资。公司专注"清除、激活、重编程衰老细胞"三大平台，两条核心管线分别针对呼吸系统与眼科疾病，今年3月同步获NMPA与FDA的IND批准，成为中国首个获FDA许可进入临床的抗衰老创新药。

ENvcbeat.top reports that Nanjing-based Ruichu Biopharma announced a nine-figure oversubscribed Series A on October 21, backed by Cathay Capital, Fuxing Capital, Yifeng Capital and Huatai Gensight. Built on senolytic, seno-activating and reprogramming platforms, its two lead programs target respiratory and ocular diseases and received IND approvals from both the NMPA and the FDA in March, making them the first Chinese anti-aging drugs cleared by the FDA to enter clinical trials.

中鲁网解析华西医院NKG2D-CAR-T抗衰老技术：该定制化CAR-T靶向衰老细胞表面高表达的NKG2D配体，在小鼠及恒河猴、食蟹猴实验中显著降低脂肪组织衰老标志物，心肝肾未见明显异常。技术仍处临床前阶段，专利2026年9月已转让给循源医疗科技，计划下半年在海外启动研究者发起的临床试验。

ENLuzhong News examines the NKG2D-CAR-T anti-aging technology from West China Hospital: the customized CAR-T targets NKG2D ligands highly expressed on senescent cells and markedly reduced senescence markers in adipose tissue of mice and non-human primates without observable liver, kidney or cardiac toxicity. Positioned for aging intervention rather than cancer, it remains preclinical; the patent was transferred to ORIGO Group in September 2026, with investigator-initiated trials planned overseas later this year.

中成都大学举办"衰老与主动健康"前沿报告会：四川大学赵旭东借鉴免疫系统清除衰老细胞的机制，探索CAR-T、双特异性抗体等仿生抗衰手段，临床前效果良好并推进临床；昆明动物所孔庆鹏团队依托长寿人群多组学图谱，鉴定出ETS1、ATF7等调控因子，揭示自噬溶酶体激活等长寿分子特征。

ENChengdu University's School of Basic Medical Sciences hosted a frontier symposium on aging and proactive health: Sichuan University's Zhao Xudong explores biomimetic senescent-cell clearance via CAR-T and bispecific antibodies, with strong preclinical results and clinical trials underway; Kuncheng Peng's team at the Kunming Institute of Zoology mined multi-omics profiles of long-lived cohorts over 90, identifying regulators such as ETS1 and ATF7 and hallmarks including activated autophagy-lysosome pathways and enhanced lipid metabolism.

中第十一届江南食品产业论坛食药同源与精准营养论坛举行，专家指出我国营养健康产业正告别成分概念营销，迈向精准化、场景化、合规化。西北农林科大刘学波提出肠-肝-脑轴调控与肠神经系统新靶点，王刚呼吁益生菌按生命阶段精准匹配，后生元赛道升温但循证证据链仍待补齐。

ENAt the 11th Jiangnan Food Industry Forum's food-medicine homology and precision nutrition session, experts said China's nutrition industry is moving past ingredient hype toward precision, scenario-based and compliant development. Liu Xuebo of Northwest A&F University proposed gut-liver-brain axis regulation and the enteric nervous system as intervention targets, while Jiangnan University's Wang Gang urged life-stage-matched probiotic strategies grounded in domestic strains and clinical evidence, noting postbiotics' rise and unresolved evidence gaps.

中伊迪斯科文大学团队发表随机双盲试验：抗性淀粉与洋车前子壳配伍的纤维复方"ur gut"，让低FODMAP饮食的肠易激综合征患者在症状保持稳定的同时，肠道菌群显著改善、肠相关焦虑下降。洋车前子延缓抗性淀粉发酵使其深入结肠，为突破"限食伤菌"困境提供新路径。

ENEdith Cowan University researchers report in the European Journal of Nutrition a randomized double-blind trial of "ur gut", a blend of resistant starch and psyllium husk: IBS patients on a low-FODMAP diet maintained stable pain and bloating while showing marked microbiota improvements and reduced gut-related anxiety. Psyllium delays fermentation of the starch so it reaches deeper colon segments, offering a way out of the low-FODMAP dilemma of symptom relief at the cost of beneficial microbes.

中德国DZNE研究发现，健康饮食与更慢的生物衰老相关，且实现途径不止一种：研究考察地中海饮食、北欧饮食等十种被视为健康的饮食模式，均与延缓生物学衰老有关。这提示无需执着于单一"最佳饮食"，长期坚持任一科学膳食框架即可获得抗衰老收益，也为不同文化背景与口味偏好的人群保留了个性化选择空间，降低了执行门槛。

ENGerman DZNE researchers found that healthy eating is associated with slower biological aging — and there is more than one way to do it: across ten dietary patterns considered healthy, from Mediterranean to Nordic diets, all were linked to delayed biological aging. The takeaway: there is no single "best diet"; sustained adherence to any science-based pattern brings anti-aging benefits while leaving room for personal and cultural preferences.

中重庆医科大学第二附属医院等团队发表研究：本土AKK菌株干预2型糖尿病模型小鼠后，甘油三酯与总胆固醇分别下降25.87%和49.22%，高密度脂蛋白上升47.77%，肝脏脂滴减少、胰岛获保护。AKK菌丰度随年龄与不良饮食下降，该本土菌株为代谢营养干预提供新方向。

ENA team from the Second Affiliated Hospital of Chongqing Medical University and collaborators reported in the Journal of Functional Foods that a domestic Akkermansia muciniphila strain improved metabolism in type 2 diabetic mice: triglycerides fell 25.87%, total cholesterol 49.22%, HDL rose 47.77%, with less hepatic lipid accumulation and protected islets. AKK abundance declines with age and unhealthy diets, positioning the strain as a new lead for metabolic nutrition interventions.

中NutraIngredients援引中国医药保健品进出口商会报告：2026上半年鱼油进口额同比增长60.07%至3.84亿美元，其中自秘鲁进口激增182.8%，采购渠道加速向拉美拓展。线上鱼油销售额同比增长44.91%；复合维生素仍居畅销首位，美国、德国进口份额下降，进口来源趋于多元化。

ENCiting a CCCMHPIE report, NutraIngredients notes China's fish oil imports rose 60.07% year-on-year to US$384m in H1 2026, nearly 10% of supplement imports, with Peruvian shipments surging 182.8% as sourcing expands into Latin America. Online fish oil sales grew 44.91%; multivitamins remained the top-selling category, ahead of calcium and probiotics, while US and German import shares fell, signaling increasingly diversified sourcing.

中FDA膳食补充剂项目办公室主任Cara Welch表示，正重新审视"膳食物质"法定定义的解读，或出台专项指南草案，明确其对微生物等成分类型与生产方式的适用。FDA欢迎行业协会牵头编制DSHEA前上市成分清单并愿成为主要使用者；她建议拟用于补剂的新成分优先走NDI审查而非借GRAS规避审核。

ENCara Welch, director of FDA's Office of Dietary Supplement Programs, told CRN Convergence 2026 that the agency is reexamining its interpretation of the statutory "dietary substance" definition and may issue a draft guidance clarifying how it applies to ingredient types such as microorganisms. FDA welcomed trade associations building a pre-DSHEA ingredient list and would be a major user, while urging that novel supplement ingredients go through NDI review rather than using the GRAS pathway to avoid oversight.

中Better Dairy宣布其精准发酵乳桥蛋白获美国自认定GRAS地位，为全球首个此类商业化供应。乳桥蛋白是天然存在于人乳与牛乳中的信号蛋白，参与组织生长修复，可用于健康衰老、肠道、免疫与运动恢复方向，并与胶原、乳铁蛋白协同。该原料将在SupplySide Global 2026亮相。

ENBetter Dairy has achieved self-affirmed GRAS status in the US for its precision-fermented lactopontin, billed as the world's first commercial supply. A signaling protein naturally found in human and cow milk involved in tissue growth, repair and renewal, lactopontin supports products for healthy aging, gut, immune, joint and skin health and sports recovery, and synergizes with collagen, lactoferrin and probiotics. The ingredient debuts at SupplySide Global 2026 as EU and Asia pathways progress.

中一项令人意外的临床试验显示，每日服用维生素C可能改善癌前血液疾病及早期血液癌症患者的生存率：服用该补充剂的患者不良事件更少，结果颇具前景。研究者强调这属于探索性发现，维生素C并非抗癌疗法，常规大剂量服用须遵医嘱；但结果有望推动针对骨髓增生异常等高危人群的进一步验证，为低成本营养辅助干预提供线索。

ENA surprising clinical trial suggests daily vitamin C may improve survival in patients with pre-malignant blood disorders and early blood cancers, with fewer adverse events among those taking the supplement. Researchers stress this is an exploratory finding — vitamin C is not an anticancer therapy and high-dose use needs medical guidance — but the results should prompt further validation in high-risk groups such as myelodysplastic syndromes, pointing to low-cost nutritional adjuncts.

中深圳龙岗区以192家社康机构为网底构建步行15分钟医疗服务圈，高血压、糖尿病患者每年可获不少于4次面对面随访与免费体检；"龙岗家医"小程序注册用户超74万，智能设备数据互通，AI健康画像对异常指标双向告警，探索慢病"防、筛、管、治、康"全周期管理延伸至社区与家庭。

ENLonggang District in Shenzhen has built a 15-minute medical service circle on 192 community health centers, giving hypertension and diabetes patients at least four face-to-face follow-ups and a free annual check-up. The "Longgang Family Doctor" mini-program has over 740,000 registered users; connected smart BP/glucose devices feed AI-generated health profiles with two-way alerts for abnormal readings, extending full-cycle chronic-disease management from hospitals into communities and homes.

中沉浸式科学减重科普IP"轻盈巴士"10月16日在天津北辰启动，医院专家现场坐诊，通过体成分检测、脂肪肝及肝硬度无创筛查帮助市民走出盲目节食与过度运动误区。北辰区将体重管理嵌入10个慢病管理中心与14个星级糖尿病门诊，重点人群家庭医生签约覆盖率达98%。

ENThe immersive weight-management education IP "Lightness Bus" opened in Tianjin's Beichen District on October 16, with hospital clinicians offering InBody body-composition tests and non-invasive fatty-liver screening while debunking crash dieting and over-exercise myths. Beichen embeds weight management into 10 chronic-disease centers and 14 diabetes clinics, with 98% family-doctor coverage among key groups and Tianjin's first Level-4A health-information interoperability rating.

中新华社报道老年慢病防控新生态：国家慢性病综合防控示范区已达578个，"三减三健"覆盖2800多个县区。"银龄智健行"项目启动，构建"筛查—干预—管理—支持"全周期体系；专家提出干预从通用化向精准化、个性化转变，上海中医药大学展示中西医结合应对老年肌少症与脂肪肝共病的实践。

ENXinhua reports on China's evolving elderly chronic-disease control: 578 national demonstration zones and the "Three Reductions, Three Healths" campaign now cover over 2,800 counties. The newly launched "Silver Age" self-health and Smart Health initiatives aim to build a full-cycle screening-intervention-management-support system, with experts urging a shift from generic to precision, personalized intervention; Shanghai University of TCM showcased integrated approaches to sarcopenia-fatty liver comorbidity in the elderly.

中儿童肠菌移植技术联盟成立暨学术论坛10月19日在深圳市儿童医院龙华院区举行，肠道微生态诊疗与临床研究中心同步挂牌，推动珠三角儿童肠菌移植规范化与多中心研究。专家梳理儿童益生菌科学选菌三原则：功效精确到株、足量与活性有保障、按年龄段安全合规，并强调本土循证证据是儿童精准营养的关键。

ENA pediatric fecal microbiota transplantation technology alliance was founded on October 19 at Shenzhen Children's Hospital Longgang campus, alongside a gut-microecology clinical research center, to standardize pediatric FMT and drive multicenter studies in the Greater Bay Area. Experts outlined three principles for strain-specific probiotic selection in children — evidence tied to named strains, guaranteed potency and viability, and age-appropriate safety compliance — stressing local-population evidence as key to pediatric precision nutrition.