全球健康与长寿每日简报Global Health & Longevity Daily Briefing

中研究提出「代谢生物学年龄差值」量化长期累积的稳态负荷，发现中年阶段存在宿主与菌群的衰老时差：微生物功能衰退早于全身衰老的临床表现。一旦稳态负荷越过代偿临界点，1,3,7-三甲基尿酸富集、全反式维甲酸耗竭等特征代谢物变化便推动系统性衰老，提示体检正常不等于菌群未老。

ENThe study proposes a metabolic biological-age gap to quantify cumulative allostatic load, revealing a host-microbiome ageing mismatch in midlife: microbial functional decline precedes clinical signs of systemic ageing. Once load crosses the compensation threshold, metabolite shifts such as 1,3,7-trimethyluric acid accumulation and all-trans-retinoic acid depletion drive systemic ageing, so a normal check-up does not mean an unaged microbiome.

中团队锁定编码 5-oxoETE 合成酶的基因 DHRS7 及其受体 OXER1，发现这条经典「招募免疫细胞」的警报通路同时保护邻近健康细胞免受免疫反应产生的化学应激，机制依赖 NUDIX 水解酶。抑制该通路反而加重炎症；炎症性肠病患者肠组织 5-oxoETE 偏低与更差结局相关。

ENResearchers identified DHRS7 as the gene encoding the 5-oxoETE synthase and OXER1 as its receptor, showing that this classic immune-cell recruiting alarm also shields neighbouring healthy cells from the chemical stress of the immune response, via NUDIX hydrolases. Blocking the pathway worsens inflammation, and low intestinal 5-oxoETE in IBD tracks with poorer outcomes.

中综述梳理猕猴桃干预功能性便秘与便秘型肠易激综合征的机制与临床证据：最一致的方案是每日两个新鲜绿心猕猴桃、持续约 4 周，对排便次数与粪便性状的改善与车前子、西梅大致相当，且耐受性良好。作者强调证据以绿心鲜果最强，粉剂与提取物不可假定临床等效。

ENA review of mechanisms and clinical evidence for kiwifruit in functional constipation and IBS-C finds the most consistent regimen is two fresh green kiwifruit daily for about four weeks, improving bowel frequency and stool form comparably to psyllium or prunes with good tolerability. Evidence is strongest for fresh green fruit; powders and extracts should not be assumed equivalent.

中FMC 2026 第四届功能医学行业论坛定于 11 月 21–22 日在上海富悦大酒店举办，由 FMC 功能医学教育平台组织，会期两天、九大专题论坛并行，覆盖功能医学与慢性疾病、个性化营养、抗衰老与长寿医学、长寿诊所运营等方向，并设临床案例大赛与专题工作坊。

ENFMC 2026, the fourth Functional Medicine Industry Forum, runs Nov 21-22 at Shanghai Fuyue Hotel, organised by the FMC functional medicine education platform, with nine parallel tracks spanning functional medicine and chronic disease, personalised nutrition, anti-ageing and longevity medicine, and longevity clinic operations, plus a clinical case competition and workshops.

中立陶宛团队对 1068 人完成 1340 次全血 NAD 检测，发现健康人 NAD 不随年龄下降，但心血管疾病与高血压患者显著下降。每日口服 1000 mg NMN 可把 NAD 从约 19–20 μM 推高到 51–56 μM，半衰期 3.2–4.3 天，远超生理范围，长期安全性未知。

ENA Lithuanian team ran 1,340 whole-blood NAD measurements in 1,068 adults and found NAD does not fall with age in healthy people (flat in men, rising slightly in women), yet declines markedly in cardiovascular disease and hypertension. Daily 1,000 mg NMN raised NAD from about 19-20 microM to 51-56 microM with a 3.2-4.3 day half-life, far above physiological range, with unknown long-term safety.

中论坛 10 月 31 日在上海科技大学举办，为该主题首次落地张江。清华大学王钊从进化生物学角度指出，遗传只是衰老影响因素之一，生活方式与环境可有效调控进程；与会专家围绕本土人群甲基化衰老时钟、基因重编程、中医体质分型与「未病先防」展开讨论，倡导个体化全周期健康管理。

ENHeld Oct 31 at ShanghaiTech University and the first of its kind in Zhangjiang, the forum heard Tsinghua's Wang Zhao argue from evolutionary biology that genes are only one ageing factor while lifestyle and environment can modulate the process. Experts discussed methylation clocks for Chinese populations, gene reprogramming, TCM constitution typing and individualised whole-lifecycle health management.

中中国营养学会与中国疾控中心在京召开健康长寿研究专题研讨会，施小明团队报告高龄老年人健康评价与促进研究：血压、血脂、体质指数与死亡风险和认知功能的关联需结合年龄与功能状态解读；休闲活动在较年轻老年人中作用突出，膳食营养在高龄阶段更为关键，并已开发认知障碍风险评估工具。

ENAt a Beijing symposium co-hosted by the Chinese Nutrition Society and China CDC, Shi Xiaoming's team reported that links between blood pressure, lipids, BMI and mortality or cognition must be read alongside age and functional status; leisure activity matters most in the younger-old and diet in the oldest-old. A cognitive impairment risk tool was also released.

中美国 HHS 发布临时执法裁量政策，允许在厂家资质、产品检测、患者个体处方与不良事件报告条件下有限配制 BPC-157、Epitalon、KPV、MOTS-c、Semax 与 TB-500。Elysium 宣布经处方渠道提供这六种肽，并推出 PEER 科研供应计划与 TIME-PEP 表观遗传研究。

ENA new HHS interim enforcement-discretion policy permits limited compounding of BPC-157, Epitalon, KPV, MOTS-c, Semax and TB-500 subject to manufacturer qualification, product testing, patient-specific prescriptions and adverse-event reporting. Elysium will offer the six peptides through its prescription channel and launched the PEER research-supply programme and the TIME-PEP epigenetic study.

中研究整合日本人群多组学与中介分析，刻画饮食、饮酒等可改变生活方式如何经肠道菌群影响健康与疾病风险：膳食纤维、豆类、发酵食品与咖啡指向产丁酸菌，精制糖则富集口腔来源菌与乳酸产生菌并伴随促炎特征。据此构建的 MADE 评分可区分健康与多种疾病，并在外部人群获得验证。

ENIntegrating multi-omics and mediation analysis in a Japanese cohort, the study maps how modifiable behaviours such as diet and alcohol act through the gut microbiome: fibre, legumes, fermented foods and coffee track with butyrate producers, while refined sugar enriches oral-derived and lactic-acid bacteria alongside pro-inflammatory signatures. The derived MADE scores separated health from multiple diseases and validated externally.

中第九届进博会上，华大集团展出覆盖测序装备、智能健康体系与精准健康消费品的完整矩阵，智能健康终端「i³智舱」入选中国馆；华大智造呈现全读长测序、智能自动化与多组学「底层基座」，华大营养则推出「益人益方」个性化肠道健康方案与个性化营养素，把多组学落到日常健康消费。

ENAt the ninth CIIE, BGI Group showed a full matrix from sequencing hardware to smart health systems and precision consumer products, with its i-cubed smart health cabin selected for the China Pavilion. MGI presented all-read-length sequencing, lab automation and multi-omics infrastructure, while BGI Nutrition launched the Yirenyifang personalised gut-health and nutrient programmes.

中90 名男性痛风患者随机对照试验显示，在常规健康教育之上叠加 42 天低嘌呤限能量平衡膳食，血尿酸较基线下降 112.4 μmol/L（对照组 47.0），尿酸排泄分数提高 0.87%，达标率由 11.1% 升至 71.1%（对照组 40%），红肉、甜点与烹调油摄入减少，蔬菜、鸡蛋与乳制品增加。

ENIn a 90-patient randomised trial, 42 days of a structured low-purine, energy-restricted balanced diet on top of standard education lowered serum urate by 112.4 micromol/L versus 47.0 in controls, raised fractional urate excretion by 0.87 percentage points and lifted target attainment from 11.1% to 71.1% (controls 40%), with less red meat, dessert and cooking oil and more vegetables, eggs and dairy.

中Solnul 抗性马铃薯淀粉开展 4 周随机双盲安慰剂对照复现试验，74 名健康成人每日 3.5 g：符合方案集分析中双歧杆菌增幅优于安慰剂，但扩大分析人群后差异不显著；Akkermansia 较基线升高却未显著优于安慰剂，主要终点未达。胃肠道耐受性良好，无严重不良事件。

ENA four-week randomised, double-blind, placebo-controlled replication of Solnul resistant potato starch gave 74 healthy adults 3.5 g daily: Bifidobacterium rose more than placebo in the per-protocol set but not in the broader population, and Akkermansia increased from baseline without beating placebo, missing the primary endpoint. Gastrointestinal tolerability was good, with no serious adverse events.

中萨里大学主导的 STAMINA 试验纳入 61 名健康成人，33 人每日服用含维生素、矿物质、氨基酸与植物活性物的复合配方，28 人服安慰剂六个月。结果显示血流介导舒张改善（首剂一小时内即出现）、收缩压较对照低 6.1 mmHg、脉搏波速度低 1.18 m/s，血脂无变化；样本量小，属概念验证。

ENThe Surrey-led STAMINA trial gave 33 of 61 healthy adults a multivitamin, mineral, amino acid and plant-bioactive blend and 28 a placebo for six months. Flow-mediated dilation improved, detectable within an hour of the first dose, systolic pressure was 6.1 mmHg lower and pulse wave velocity 1.18 m/s lower than control, with no lipid change. Small and proof-of-concept only.

中Innova 数据显示 2022–2025 年肌酸增速为整体补剂市场三倍，2026 年 1–8 月含肌酸新品同比增 62%，健身房之外场景的新品增幅达 194.7%。价格分层：原味粉每公斤 73 欧元，调味粉 83 欧元，加生物活性物的「肌酸+」222 欧元，软糖、咀嚼片等剂型 275 欧元。

ENInnova data show creatine grew at three times the wider supplement market in 2022-2025, with launches containing it up 62% year on year in January-August 2026 and non-gym launches up 194.7%. Pricing is highly tiered: a median 73 euros per kilo for plain powder, 83 flavoured, 222 for creatine-plus with bioactives and 275 for gummies, chews and bars.

中南昆士兰大学团队评估印度 Akay Bioactives 的辣椒素原料 Capsifen 对超重或肥胖中老年人脑血管功能与认知的影响，发现补充组总脑血管反应性升高，反映神经元代谢需求增加时脑血流调配能力增强。作者称这是初步证据，机制涉及一氧化氮可用性、氧化应激与炎症。

ENUniversity of Southern Queensland researchers tested Akay Bioactives' Capsifen in overweight or obese middle-aged and older adults, finding total cerebrovascular responsiveness rose in the supplement group, reflecting better blood-flow matching to neuronal metabolic demand. The authors call it preliminary evidence, with nitric oxide availability, oxidative stress and inflammation as mechanisms.

中据 NIE 公布资料，AKK001 相关研究为 90 天、60 名超重或肥胖受试者的随机安慰剂对照试验，采用 AKK001 与三丁酸甘油酯复配的落地方案，体重、体脂率、腰围及多项代谢指标向好，甘油三酯 12 周下降 21%。报道同时提示，联合干预结果不能简单归因于单一菌株，仍需更多验证。

ENAccording to NIE materials, the AKK001 study was a 90-day randomised placebo-controlled trial in 60 overweight or obese participants using a combination of AKK001 and tributyrin; weight, body-fat percentage, waist circumference and several metabolic markers improved, with triglycerides down 21% at 12 weeks. The report cautions that combination results cannot be credited to a single strain.

中山西省卫健委发布会提出「五个推动」：依托县级医疗集团实体化建设慢病管理中心，实行「专科医师+全科医师+公卫医师」三师共管与「医师+药师+护士」三岗联动；省财政投入 6 亿元分两批支持 30 个县实施紧密型县域医共体升级版，首批 15 个县已由副县长兼任中心主任。

ENShanxi's health commission outlined five pushes: building chronic-disease centres inside county medical groups with a three-physician, three-role care model; and 600 million yuan in provincial funding for 30 counties to upgrade tight county medical communities, with the first 15 counties already chaired by vice-county heads.

中浙江将体重管理纳入健康浙江行动，十五部门联合出台「体重管理年」实施方案，已推动 11 个设区市和 38 个县（市、区）成立健康体重指导中心，全省 361 家医疗机构提供体重管理门诊，普遍采用内分泌、营养、运动、心理多学科模式，构建「筛查—干预—随访」链条；中医治未病科设置率达 100%。

ENZhejiang has folded weight management into Healthy Zhejiang, with 15 departments issuing a weight-management year plan. Guidance centres now exist in 11 cities and 38 counties, and 361 hospitals offer weight clinics using multidisciplinary endocrine, nutrition, exercise and psychology teams along a screen-intervene-follow-up chain; TCM preventive-care units reach 100% of public TCM hospitals.

中辉瑞中国计划 2026 年下半年至 2027 年在全国协助落实 500 家医院体重健康管理门诊，并重点打造 100 家标杆。其广阔市场事业部观察到，一线城市减重多指向外形与幸福感，县域人群则多在出现功能性障碍后才就诊，存在明显时间差；企业将配合主管部门为县域医护提供系统培训。

ENPfizer China plans to help set up weight-management clinics in 500 hospitals between late 2026 and 2027, with 100 developed as benchmarks. Its broader-market unit notes that in tier-1 cities weight loss is driven by appearance and wellbeing, while county patients usually present only after functional problems appear, a dangerous time lag. Training for county clinicians is part of the plan.

中国家医保局明确支持基层为符合条件的慢性病患者开具长期处方，健全医共体内药品采购、配送、使用一体化管理，推进处方规范流转和用药衔接。地方层面，苏州允许符合条件的社区卫生服务中心与养老机构内设医疗机构不受规划数量限制纳入医保定点，杭州要求每个街道或乡镇至少有一家一级及以下定点机构。

ENThe NHSA explicitly backs long prescriptions for eligible chronic-disease patients in primary care, integrated drug procurement, delivery and use within medical communities, and orderly prescription circulation. Locally, Suzhou exempts qualifying community health centres and elderly-care facilities from planning quotas for insurance designation, while Hangzhou requires at least one tier-1-or-lower designated provider per subdistrict or township.